This paper presents the research work involved in the development of a knowledge-based framework for the design of millimeter-wave 60 GHz radio over fiber (RoF) land networks. It combines object-oriented, rule-based, technical information, and procedural functions to support engineers in the conceptual and preliminary design of a network. The overall framework is organized in two main modules: the first module is a tutorial of the terminology and basic principles in the design of RoF networks. The second module is a design assistant system that requests input data from the user about the functional network requirements and its prioritized figures of merit. The proposed design assistant is capable of providing support on the major activities of the 60 GHz RoF land network design such as downlink and uplink channel assignment and network clustering, wavelength allocation, optical link design, and network integration. The assistant is user interactive through the implementation of a graphical user interface. To illustrate the validation of such framework, we present a case of study of a network design with specific requirements.