“…The efficient and regiospecific alkyne-azide-click reaction, also known as the Cu-catalyzed Alkyne-Azide Cycloaddition reaction (CuAAC), has become a common approach for the stereoselective synthesis of the 1,4 regioisomer of 1,2,3-triazoles. As a part of our efforts toward the synthesis of new bioactive heterocyclic systems with a basic terpenic skeleton [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ], we have recently reported the interesting anticancer activities of some 1,4-disubstituted 1,2,3-triazolic compounds newly prepared from Eugenol and (R)-carvone monoterpene [ 38 , 39 ]. These promising findings prompt us to extend our interest in the synthesis ofother 1,4-disubstituted 1,2,3-tiazoles from another natural monoterpene.…”