The use of exoskeletons promises improved ergonomics, empowerment of users and prevention of musculoskeletal disorders. However, the development process is complex and a generic development methodology that will guide and assist designers through it is missing. The goal of this paper is to describe a methodological approach that will assist the conceptual design of exoskeletons. Based on derived methodological requirements, activities 1, 2, and 3 of the VDI 2221 (Methodology for the development of technical products) are specified to adapt the generic guideline to the development process of exoskeletons. These activities include the analysis and determination of the relationship between the use case, product requirements and motions, technical functions, and design solutions. For generating a list of product requirements designers must focus on the workers’ motions and needs for a for a task-specific and personalised development. Use case specific movements are generalised by using rotational and translational basic movements that result in six degrees of freedom and from which a function structure is derived. The method is critically reviewed based on the established methodological requirements.