With the development of technology and technological updates, mobile phones have become more and more powerful, which has provided a strong guarantee for the flourishing of mobile games. The convenience and social nature of mobile gaming have led to more and more people getting into it, making it one of the choices in people's daily entertainment lives. The application of new media technology to mobile games has led to an increasingly user-friendly design that is more attuned to the interests and habits of users, and one of the most popular areas of research is the design of the human-computer interaction interface. As an important medium for human interaction with games, the interface has a deep impact on the quality of the game, and a good interface design will largely enhance the user experience and increase the attractiveness of the product, thus effectively promoting user growth. Therefore, this paper will elaborate on the topic of HMI design in mobile games, discussing the relationship between mobile games and art design, exploring the design strategies, and discussing and analyzing some design elements from the perspective of user use. The design of a mobile game interface is based on the principles of consistency between art style and theme, simplicity and ease of use, unity and harmony of design style, and user-oriented design, which provide theoretical reference for future mobile game interface design.