Design, Multicomponent Synthesis and Characterization of Diversely Substituted Pyrazolo[1,5‐a] Pyrimidine Derivatives

Abstract

The synthesis of various heterocyclic compounds using acetoacetanilide[AAA], we have demonstrated that acetoactanilide are versatile intermediate for the synthesis of pyrazolopyrimidine derivatives. Thus, to explore further, we sought that the reaction of various acetoactanilide, an appropriate aldehyde and 5‐amino‐N‐cyclohexyl‐3‐(methylthio)‐1H‐pyrazole‐4‐carboxamide in the presence of base in isopropyl alcohol could be an effective strategy to furnish the novel pyrazolopyrimidine derivatives. Here we describe the novel synthetic methodology for the fused pyrazolopyrimidines.

Design, Synthesis, Antimicrobial and Docking Studies of Benzothiazoles Bearing Pyrazole and Pyrimidine Moieties

“…[22,23] They utilized antitrypanosomal, antimetabolites in purine biochemical interactions, sedative and antitrypanosomal, kinase inhibitors, HIV (human immunodeficiency viruses), reverse transcriptase inhibitors, as well as antifungal and antimalarial properties. [24][25][26][27]…”

“…Due to their pharmacological properties, pyrazolopyrimidines known as purine analogs have attracted a lot of research [22,23] . They utilized antitrypanosomal, antimetabolites in purine biochemical interactions, sedative and antitrypanosomal, kinase inhibitors, HIV (human immunodeficiency viruses), reverse transcriptase inhibitors, as well as antifungal and antimalarial properties [24–27] …”

Utilization of 5‐Chloro‐2‐(cyanoacetamido)pyridines in the Synthesis of Biologically Active Heterocyclic Hybrids

“…The nucleophilic position C‐2 is more reactive than NH, while the electrophilic site C‐3 is more reactive than position C‐1. Cyanoacetamides (Figure ) are highly reactive polyfunctional substrates for preparing of structurally diverse five and six membered heterocycles including pyrazoles, thiazoles, thiophenes, and pyridines . The latter heterocycles that contain one or two heteroatoms have attracted researchers due to their wide range of biological activities .…”

Synthesis and Antibacterial Evaluation of Some New Thiazole‐Based Polyheterocyclic Ring Systems

“…N ‐Thiazol‐2‐yl cyanoacetamide ( R = 2‐thiazolyl) allows introduction of an additional diversity nucleophilic point into the molecule via nitrogen atom of thiazole. Cyanoacetamides derivatives have been utilized as highly reactive polyfunctional precursors for the construction of various 5‐membered and 6‐membered rings such as pyrrole , pyrazole , thiazole , thiophene , pyridine , pyrimidine , isoquinoline derivatives , and fused heterocycles .…”