Design of 1‐(2‐pyrrolidinone)‐butane‐1,3‐dione derivatives and acetoxylation of these compound's methylene via hypervalent iodine (III)

Abstract

An interesting synthesis method for 2‐acetate‐1‐(2‐pyrrolidinone)‐butane‐1,3‐dione compounds was developed in this work. The synthesis of these compounds was carried out in three steps. In the first step, 2‐pyrrolidone derivatives were obtained by the Friedel‐Crafts reaction in presence of Eaton's reagent. Then, ‐NH group of 2‐pyrrolidone compounds were attached acetoacetate group in presence of 2,6‐trimethyl‐4H‐1,3‐dioxin‐4‐one reagent. Lastly, 1‐(2‐pyrrolidinone)‐butane‐1,3‐dione derivatives were reacted with Pida to attach acetoxy group to these compound's methylene.

Synthesis of 1,3‐oxazepine derivatives via tandem reaction of 5‐benzylidine Meldrum's acids with TosMIC in presence of potassium carbonate

“…5-Benzylidine Meldrum's acid derivatives are among the most important substrates used by researchers in organic synthesis in recent years [18,19]. Knowing ketene chemistry from my previous studies [20][21][22], the Meldrum's acid derivatives decompose to ketene, releasing CO 2 and acetone [23]. Therefore, Meldrum's acid (2,2-dimethyl-1,3-dioxane-4,6-dione) (12) and aldehyde derivatives (13) were first reacted in acetonitrile in presence of piperidine to give 5-benzylidine Meldrum's acid derivatives (14) at the end of 3 h at 82 C [19].…”