900 nm Nd-doped fiber laser can find widespread applications including biomedical diagnosis, laser detection, and spectral analysis. However, the four-level (<sup>4</sup>F<sub>3/2</sub>→<sup>4</sup>I<sub>11/2</sub>) gain competition of Nd<sup>3+</sup> around 1060 nm severely constrains the laser power scaling of the 900 nm three-level (<sup>4</sup>F<sub>3/2</sub>→<sup>4</sup>I<sub>9/2</sub>) Nd-doped fiber laser. Recently, anti-resonant fiber based on anti-resonant guiding mechanism has attracted intense attention due to its properties of wide transmission band, low transmission loss, and high mode purity under large core size. In this work, we propose a large-mode-area Nd-doped double-layer solid-core anti-resonant fiber with core diameter of 27 μm for high-power 900 nm laser generation based on the resonant and anti-resonant conditions of anti-resonant fiber. The transmission properties and mode profiles of the designed fiber are analyzed theoretically with the full-vector finite-element method combined with optimized mesh size. By introducing the double-layer anti-resonant elements into the active fiber and optimizing the fiber structure parameters and refractive index distribution, the high-order modes are well coupled with cladding modes. Finally, the designed fiber exhibits a confinement loss below 0.1 dB/m for fundamental mode and those of all high-order modes are greater than 10 dB/m in 880-913 nm band. More importantly, the confinement losses of all modes are up to 100 dB/m around 1060 nm, which allows the designed Nd-doped fiber for efficient parasitic lasing and even amplified spontaneous emission suppression. The Nd-doped solid-core anti-resonant fiber proposed in this paper shows broad application prospects in the fields of 900 nm high-power fiber laser and amplifier. The developed chemical vapor deposition process combined with stack-and-draw technology can be adopted for the fabrication of the designed fiber. To guarantee the optical performance of the anti-resonant fiber, it is necessary to accurately control the thicknesses of all anti-resonant tubes, the glass composition of the active core and background regions in practical fabrication. The power handing capability of the designed fiber is mainly constrained by the structure defects and material impurity introduced during the fabrication process, and the nonlinear effects under high laser power is another factor that should to be considered to improve the power handing capability of the proposed fiber.