This thesis studies the problem of three-dimensional guidance considering maneuvering acceleration and input saturation based on the background of missile intercepting maneuvering target. On the basis of the three-dimensional guidance model with impact angle constraints, an adaptive integral sliding mode three-dimensional guidance law is designed using integral sliding mode control theory and adaptive algorithm. By introducing an auxiliary system, an adaptive anti-saturation integral sliding mode three-dimensional guidance law is designed, which can solve the problem of input saturation, The stability of the designed guidance law is proved by Lyapunov theory, which ensures that the sliding mode manifold converges to zero in finite time. The effectiveness of the designed guidance law is verified by simulation analysis.