Design of a ‘‘beetle-type’’ atomic force microscope using the beam deflection technique

Gasser, B.; Menck, Alexander; Brune, Harald; Kern, Klaus

doi:10.1063/1.1146998

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…The values of Q and k that are used in practice cover a wide range of values. For example, the spring constant of microfabricated cantilevers is usually in the range of kϭ0.01-0.5 N/m, 14,15 and a value of Q in the order of 6 has been determined for a microcantilever used in a commercial AFM. 12 On the other hand, a homefabricated cantilever using a section of an optical fiber which was used in a near-field scanning optical microscope 16 had a spring constant of kϭ80 N/m and a Q factor of 290.…”

Section: Comparison Of the Source-induced Noise With The Thermal-vmentioning

confidence: 99%

Noise in optical measurements of cantilever deflections

Garcı́a-Valenzuela

Villatoro

1998

Journal of Applied Physics

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The optical beam deflection method using the knife edge detection technique is one of the simplest optical sensing methods. We investigate theoretically the limit to the resolution when sensing the displacements of a mechanical cantilever using the knife edge detection technique implemented with a quasimonochromatic thermal-like optical source. Simple formulas for the minimum detectable displacement of the cantilever’s front end are derived assuming all nonoptical noises negligible. It is shown that superluminiscent diodes can yield a minimum detectable displacement of the cantilever about 5 dBs above the shot noise for 1 mW of optical power. It is also shown that in many cases of practical interest the source induced noise is smaller than the thermal-vibration noise of the cantilever. Thus, in many cases, using an inexpensive thermal-like source with the knife edge detection technique can be as effective as using a high-coherence shot-noise limited source.

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Section: Comparison Of the Source-induced Noise With The Thermal-vmentioning

confidence: 99%

Noise in optical measurements of cantilever deflections

Garcı́a-Valenzuela

Villatoro

1998

Journal of Applied Physics

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“…Measurement instruments developed for small samples, when miniaturized, tend to reach a point of enabling them to be positioned on larger samples. This has been the case for the contact angle goniometer, 35 atomic force microscope ("beetle-type") 36 and portable X-ray fluorescence meters. 37 We further believe that for visualization, the microscope can be eliminated and a simple consumer-grade or cell phone camera can be used.…”

Section: Discussionmentioning

confidence: 99%

A compact and versatile microfluidic probe for local processing of tissue sections and biological specimens

Cors

Lovchik

Delamarche

et al. 2014

Review of Scientific Instruments

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The microfluidic probe (MFP) is a non-contact, scanning microfluidic technology for local (bio)chemical processing of surfaces based on hydrodynamically confining nanoliter volumes of liquids over tens of micrometers. We present here a compact MFP (cMFP) that can be used on a standard inverted microscope and assist in the local processing of tissue sections and biological specimens. The cMFP has a footprint of 175 × 100 × 140 mm 3 and can scan an area of 45 × 45 mm 2 on a surface with an accuracy of ±15 µm. The cMFP is compatible with standard surfaces used in life science laboratories such as microscope slides and Petri dishes. For ease of use, we developed self-aligned mounted MFP heads with standardized "chip-to-world" and "chip-toplatform" interfaces. Switching the processing liquid in the flow confinement is performed within 90 seconds using a selector valve with a dead-volume of approximately 5 µL. We further implemented height-compensation that allows a cMFP head to follow non-planar surfaces common in tissue and cellular ensembles. This was shown by patterning different macroscopic copper-coated topographies with height differences up to 750 µm. To illustrate the applicability to tissue processing, 5 µm thick M000921 BRAF V600E+ melanoma cell blocks were stained with hematoxylin to create contours, lines, spots, gradients of the chemicals, and multiple spots over larger areas. The local staining was performed in an interactive manner using a joystick and a scripting module. The compactness, user-friendliness and functionality of the cMFP will enable it to be adapted as a standard tool in research, development and diagnostic laboratories, particularly for the interaction with tissues and cells.3

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“…The electronics for amplification and subtraction of the four-quadrant photodiode signal was originally developed for a laser beam deflection atomic force microscope. 8 The electronic circuits were used without modification.…”

Section: Designmentioning

confidence: 99%

A micromechanical detector for molecular beams

Wicki¹,

Marsico²,

Kuhnke³

et al. 1999

Review of Scientific Instruments

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Articles you may be interested inDesign of a scanning tunneling microscope for in situ observation of the interactions of molecular beams with surfaces Rev. Sci. Instrum. 76, 083708 (2005); 10.1063/1.2005467 Field ionization detection of supersonic molecular beams Rev. Sci. Instrum. 75, 405 (2004); 10.1063/1.1642743 Signals from molecular beams using a surface ionization detector Rev. Sci. Instrum. 72, 224 (2001); 10.1063/1.1333041 Molecular beam study of the adsorption and desorption of hydrogen sulfide on Au{100}A modified molecular beam instrument for the imaging of radicals interacting with surfaces during plasma processing Rev.

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Design of a ‘‘beetle-type’’ atomic force microscope using the beam deflection technique

Cited by 5 publications

References 19 publications

Noise in optical measurements of cantilever deflections

Noise in optical measurements of cantilever deflections

A compact and versatile microfluidic probe for local processing of tissue sections and biological specimens

A micromechanical detector for molecular beams

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