Design of a new light curable starch-based hydrogel drug delivery system to improve the release rate of quercetin as a poorly water-soluble drug

Moghadam, M. Kokabi; Dorraji, Mir Saeed Seyed; Dodangeh, Fatemeh; Ashjari, Hamid Reza; Mousavi, Seyedeh Neda; Rasoulifard, Mohammad Hossein

doi:10.1016/j.ejps.2022.106191

Cited by 22 publications

(10 citation statements)

References 54 publications

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“…The hydrogel scaffolds loaded with three active agents with wound healing potential, allantoin, quercetin, and caffeic acid, were placed in a basket stirrer containing 800 mL of the release medium of phosphate buffer of pH 7.4 at 33.5 °C that simulated physiological conditions. The concentration of released allantoin, quercetin, and caffeic acid from the hydrogel scaffolds was monitored by taking the absorbance of the released media in determined time using a UV/Vis spectrophotometer (Shimadzu UV/Vis Spectrophotometer UV-1800, Kyoto, Japan) at λ max values of 204 nm (allantoin), 380 nm (quercetin), and 280 nm (caffeic acid) [ 34 , 35 , 36 ].…”

Section: Methodsmentioning

confidence: 99%

Gelatin-/Alginate-Based Hydrogel Scaffolds Reinforced with TiO2 Nanoparticles for Simultaneous Release of Allantoin, Caffeic Acid, and Quercetin as Multi-Target Wound Therapy Platform

Babić Radić,

Vukomanović,

Nikodinović-Runić

et al. 2024

Pharmaceutics

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This study proposes synthesis and evaluation of gelatin-/alginate-based hydrogel scaffolds reinforced with titanium dioxide (TiO2) nanoparticles which, through their combination with allantoin, quercetin, and caffeic acid, provide multi-target therapy directed on all phases of the wound healing process. These scaffolds provide the simultaneous release of bioactive agents and concurrently support cell/tissue repair through the replicated structure of a native extracellular matrix. The hydrogel scaffolds were synthesized via a crosslinking reaction using EDC as a crosslinker for gelatin. Synthesized hydrogel scaffolds and the effect of TiO2 on their properties were characterized by structural, mechanical, morphological, and swelling properties, and the porosity, wettability, adhesion to skin tissue, and simultaneous release features. The biocompatibility of the scaffolds was tested in vitro on fibroblasts (MRC5 cells) and in vivo (Caenorhabditis elegans) in a survival probe. The scaffolds revealed porous interconnected morphology, porosity of 88.33 to 96.76%, elastic modulus of 1.53 to 4.29 MPa, full hydrophilicity, favorable skin adhesivity, and biocompatibility. The simultaneous release was investigated in vitro indicating dependence on the scaffold’s composition and type of bioactive agents. The novel scaffolds designed as multi-target therapy have significant promise for improved wound healing in a beneficial and non-invasive manner.

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Section: Methodsmentioning

confidence: 99%

Gelatin-/Alginate-Based Hydrogel Scaffolds Reinforced with TiO2 Nanoparticles for Simultaneous Release of Allantoin, Caffeic Acid, and Quercetin as Multi-Target Wound Therapy Platform

Babić Radić,

Vukomanović,

Nikodinović-Runić

et al. 2024

Pharmaceutics

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“…Combining it with other polymers is essential due to subpar mechanical properties [72]. Light-curable, starch-based hydrogels that incorporate Fe 3 O 4 nanoparticles offer controlled quercetin release, an improved bioavailability, and enhanced mechanical properties through crosslinking under blue light [73].…”

Section: Polysaccharide-based Polymersmentioning

confidence: 99%

Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering

Rana,

De la Hoz Siegler

2024

Gels

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Hydrogels, being hydrophilic polymer networks capable of absorbing and retaining aqueous fluids, hold significant promise in biomedical applications owing to their high water content, permeability, and structural similarity to the extracellular matrix. Recent chemical advancements have bolstered their versatility, facilitating the integration of the molecules guiding cellular activities and enabling their controlled activation under time constraints. However, conventional synthetic hydrogels suffer from inherent weaknesses such as heterogeneity and network imperfections, which adversely affect their mechanical properties, diffusion rates, and biological activity. In response to these challenges, hybrid hydrogels have emerged, aiming to enhance their strength, drug release efficiency, and therapeutic effectiveness. These hybrid hydrogels, featuring improved formulations, are tailored for controlled drug release and tissue regeneration across both soft and hard tissues. The scientific community has increasingly recognized the versatile characteristics of hybrid hydrogels, particularly in the biomedical sector. This comprehensive review delves into recent advancements in hybrid hydrogel systems, covering the diverse types, modification strategies, and the integration of nano/microstructures. The discussion includes innovative fabrication techniques such as click reactions, 3D printing, and photopatterning alongside the elucidation of the release mechanisms of bioactive molecules. By addressing challenges, the review underscores diverse biomedical applications and envisages a promising future for hybrid hydrogels across various domains in the biomedical field.

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“…It improves the mechanical and release properties of the hydrogel for drug delivery. An example is the modification of starch with glycolic compounds and nanoparticles to improve quercetin release, reaching about 57% in 8 h [75].…”

Section: Starchmentioning

confidence: 99%

Renewable Polymers in Biomedical Applications: From the Bench to the Market

Lopes,

Nossa,

Lustri

et al. 2024

JRM

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Polymers from renewable resources have been used for a long time in biomedical applications and found an irreplaceable role in some of them. Their uses have been increasing because of their attractive properties, contributing to the improvement of life quality, mainly in drug release systems and in regenerative medicine. Formulations using natural polymer, nano and microscale particles preparation, composites, blends and chemical modification strategies have been used to improve their properties for clinical application. Although many studies have been carried out with these natural polymers, the way to reach the market is long and only very few of them become commercially available. Vegetable cellulose, bacterial cellulose, chitosan, poly(lactic acid) and starch can be found among the most studied polymers for biological applications, some with several derivatives already established in the market, and others with potential for such. In this scenario this work aims to describe the properties and potential of these renewable polymers for biomedical applications, the routes from the bench to the market, and the perspectives for future developments.

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Design of a new light curable starch-based hydrogel drug delivery system to improve the release rate of quercetin as a poorly water-soluble drug

Cited by 22 publications

References 54 publications

Gelatin-/Alginate-Based Hydrogel Scaffolds Reinforced with TiO2 Nanoparticles for Simultaneous Release of Allantoin, Caffeic Acid, and Quercetin as Multi-Target Wound Therapy Platform

Gelatin-/Alginate-Based Hydrogel Scaffolds Reinforced with TiO2 Nanoparticles for Simultaneous Release of Allantoin, Caffeic Acid, and Quercetin as Multi-Target Wound Therapy Platform

Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering

Renewable Polymers in Biomedical Applications: From the Bench to the Market

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