Design of a novel aptamer/molecularly imprinted polymer hybrid modified Ag–Au@Insulin nanoclusters/Au-gate-based MoS2 nanosheet field-effect transistor for attomolar detection of BRCA1 gene

Majd, Samira Mansouri; Mirzapour, Fatemeh; Shamsipur, Mojtaba; Manouchehri, Iraj; Babaee, Elaheh; Pashabadi, Afshin; Moradian, Rostam

doi:10.1016/j.talanta.2023.124394

Cited by 14 publications

(6 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, stiffer MIP matrices may be more selective; that is, it should be beneficial to prepare flexible polymeric membranes as rigid as possible 94 . Actually, electroactive polymeric membranes with relatively high Young’s moduli, such as polypyrrole (PPy) and poly( o -phenylenediamine) (PoPDA) appear to be utilized as the MIP matrices, preserving the macromolecular arrangements after the template extraction 95 – 101 . On the other hand, 2-hydroxyethylmethacrylate (HEMA), ethylene glycol dimethacrylate (EGDMA), and so forth are copolymerized to improve the hydrophilicity of MIP matrices with flexibility, which include small biomolecules and electrolytes and may show relatively low Young’s moduli, when PBA derivatives (e.g., 4-vinyl-PBA) are copolymerized in the MIP matrices on the gate electrode (Fig.…”

Section: Chemically Synthesized Electrical Interfaces For Fet-based B...mentioning

confidence: 99%

“…Even NIPs may show some affinities with target biomolecules owing to their nonspecific adsorptions and other properties, resulting in a high K a . The imprinting factor (IF) is often evaluated as one of the imprinting parameters for target biomolecules, 47 , 51 , 94 , 96 , 101 , 105 , 109 , 111 , 114 , 115 . That is, a higher IF indicates better MIP performance.…”

Section: Chemically Synthesized Electrical Interfaces For Fet-based B...mentioning

confidence: 99%

See 1 more Smart Citation

Signal transduction interfaces for field-effect transistor-based biosensors

Sakata

2024

Commun Chem

View full text Add to dashboard Cite

Biosensors based on field-effect transistors (FETs) are suitable for use in miniaturized and cost-effective healthcare devices. Various semiconductive materials can be applied as FET channels for biosensing, including one- and two-dimensional materials. The signal transduction interface between the biosample and the channel of FETs plays a key role in translating electrochemical reactions into output signals, thereby capturing target ions or biomolecules. In this Review, distinctive signal transduction interfaces for FET biosensors are introduced, categorized as chemically synthesized, physically structured, and biologically induced interfaces. The Review highlights that these signal transduction interfaces are key in controlling biosensing parameters, such as specificity, selectivity, binding constant, limit of detection, signal-to-noise ratio, and biocompatibility.

show abstract

Section: Chemically Synthesized Electrical Interfaces For Fet-based B...mentioning

confidence: 99%

Section: Chemically Synthesized Electrical Interfaces For Fet-based B...mentioning

confidence: 99%

Signal transduction interfaces for field-effect transistor-based biosensors

Sakata

2024

Commun Chem

View full text Add to dashboard Cite

show abstract

“…Ji et al also developed InSe-based FET biosensors for detecting the coronavirus [ 202 ]. Majd et al have used MoS 2 nanosheet-based FET biosensors to detect the BRCA1 gene of humans [ 203 ]. Besides detecting RNA and DNA, 2D material FET biosensors can detect viral proteins.…”

Section: Iterative Strategies Of Fetmentioning

confidence: 99%

Review on two-dimensional material-based field-effect transistor biosensors: accomplishments, mechanisms, and perspectives

et al. 2023

View full text Add to dashboard Cite

Field-effect transistor (FET) is regarded as the most promising candidate for the next-generation biosensor, benefiting from the advantages of label-free, easy operation, low cost, easy integration, and direct detection of biomarkers in liquid environments. With the burgeoning advances in nanotechnology and biotechnology, researchers are trying to improve the sensitivity of FET biosensors and broaden their application scenarios from multiple strategies. In order to enable researchers to understand and apply FET biosensors deeply, focusing on the multidisciplinary technical details, the iteration and evolution of FET biosensors are reviewed from exploring the sensing mechanism in detecting biomolecules (research direction 1), the response signal type (research direction 2), the sensing performance optimization (research direction 3), and the integration strategy (research direction 4). Aiming at each research direction, forward perspectives and dialectical evaluations are summarized to enlighten rewarding investigations.

show abstract

“…Non-conducting MIP films self-limit their growth, to allow a fine control on their thickness, while CPs are more flexible and offer the possibility to tune not only the thickness but also the conductive properties by changing the deposition conditions. The selection of polymers is strictly related to the detection methods: for example, capacitive [104] or impedimetric [105] sensors require nonconductive polymers, while for amperometric detection it is better to use conductive ones [106].…”

Section: Nanomaterials In Electrochemicalmentioning

confidence: 99%

Electrochemical Sensors for Liquid Biopsy and Their Integration into Lab-on-Chip Platforms: Revolutionizing the Approach to Diseases

Umme,

Siciliano,

Primiceri

et al. 2023

Chemosensors

View full text Add to dashboard Cite

The screening and early diagnosis of diseases are crucial for a patient’s treatment to be successful and to improve their survival rate, especially for cancer. The development of non-invasive analytical methods able to detect the biomarkers of pathologies is a critical point to define a successful treatment and a good outcome. This study extensively reviews the electrochemical methods used for the development of biosensors in a liquid biopsy, owing to their ability to provide a rapid response, precise detection, and low detection limits. We also discuss new developments in electrochemical biosensors, which can improve the specificity and sensitivity of standard analytical procedures. Electrochemical biosensors demonstrate remarkable sensitivity in detecting minute quantities of analytes, encompassing proteins, nucleic acids, and circulating tumor cells, even within challenging matrices such as urine, serum, blood, and various other body fluids. Among the various detection techniques used for the detection of cancer biomarkers, even in the picogram range, voltammetric sensors are deeply discussed in this review because of their advantages and technical characteristics. This widespread utilization stems from their ability to facilitate the quantitative detection of ions and molecules with exceptional precision. A comparison of each electrochemical technique is discussed to assist with the selection of appropriate analytical methods.

show abstract

Design of a novel aptamer/molecularly imprinted polymer hybrid modified Ag–Au@Insulin nanoclusters/Au-gate-based MoS2 nanosheet field-effect transistor for attomolar detection of BRCA1 gene

Cited by 14 publications

References 54 publications

Signal transduction interfaces for field-effect transistor-based biosensors

Signal transduction interfaces for field-effect transistor-based biosensors

Review on two-dimensional material-based field-effect transistor biosensors: accomplishments, mechanisms, and perspectives

Electrochemical Sensors for Liquid Biopsy and Their Integration into Lab-on-Chip Platforms: Revolutionizing the Approach to Diseases

Contact Info

Product

Resources

About