Design of a novel hydrogel-based intelligent system for controlled drug release

He, Hongyan; Cao, Xia; Lee, L.James

doi:10.1016/j.jconrel.2003.12.004

Cited by 175 publications

(94 citation statements)

References 26 publications

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“…[1][2][3][4][5][6] An increasing therapeutic efficiency can be realized by incorporating controlled release strategies into the design of drug carriers. [7][8][9][10][11][12] At present, some studies on bioactive particles interaction with and release from self-assembling hydrogels under elastic and reversible deformation are reported. When compared with chemically synthesized polymer materials, using peptides as the molecular building blocks for self-assembly offers the possibility of incorporating biofunctionality, such as ligand recognition, biocompatibility, and biodegradability, into the material, 13 and the corresponding hydrogels would respond to external environment under various physiological conditions.…”

Section: Introductionmentioning

confidence: 99%

Controlled release and interaction of protein using self‐assembling peptide RATEA16 nanofiber hydrogels

Zhao

Tan

Yokoi

et al. 2008

J. Polym. Sci. A Polym. Chem.

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Section: Introductionmentioning

confidence: 99%

Controlled release and interaction of protein using self‐assembling peptide RATEA16 nanofiber hydrogels

Zhao

Tan

Yokoi

et al. 2008

J. Polym. Sci. A Polym. Chem.

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“…Gels have been widely used in the delivery of drugs to the oral cavity [45]. Gels have the ability to form intimate contact with the mucosal membrane and thus there will be a rapid release of the drug at the absorption site.…”

Section: Semi-solid Buccal Adhesive Dosage Formsmentioning

confidence: 99%

Buccal Drug Delivery System : History and Recent Developments

Arun¹

2016

Asian J Pharm Clin Res

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Being an alternate method of systemic drug delivery, oral mucosal drug delivery proves to be advantageous over both injectable and enteral methods. Because of the mucosal surface usually being rich in blood supply, it enhances drug bioavailability, thereby enabling rapid drug transport to the systemic circulation. Moreover, in most cases, it avoids degradation by first-pass hepatic metabolism. The drug absorption takes place faster as it is in contact with the absorption surface. The drug delivery system helps the drug to remain at the same place of application longer for once or twice daily dosing. For some drugs, the alternate way of administration results in novel methods of action as opposed to the above-said procedure. The characteristics of the oral mucosa as well as physicochemical properties of the drug pose as a hindrance to the oral mucosal administration of some drugs. Commercial availability of drug is restricted, although most of the drugs are qualitatively assessed for oral transmucosal delivery. The clinical benefit produced by an oral transmucosal dosage form is good even though the production of this dosage form is expensive. Transmucosal products are the recent drug delivery strategies. Delivery through transmucosal products benefits the absorption 4 times than that of the skin. Considering the availability of products, only some drugs are used for oral transmucosal delivery. Hence, new drugs have to be processed and developed to meet the limited transmucosal drug delivery. The present paper intends to emphasize the importance of oral transmucosal drug delivery and also highlights on the latest advancement in the field.

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“…Şekil 6'dan da görüldüğü gibi ağırlıkça makromer oranının artmasıyla C=O, C-H, C=C ve C-O gerilme titreşimlerinin bant şiddetlerinde önemli artış olmaktadır. Gözlenen bu bariz artış yapının makromerce zenginleştiği yani söz konusu bağ sayılarının oldukça arttığı şeklinde yorumlanmıştır [23][24][25][26][27][28].…”

Section: Atr-ftir Analizleriunclassified

Photocrosslinked Poly(Ethylen Glycol) Hydrogels for Controlled Drug Delivery

Ayhan¹

2014

Turk J Bioch

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Objective: In the work presented, synthesis of PEG based hydrogels, characterization of synthesized hydrogels and usage of these hydrogels in controlled drug release systems were studied. Methods: Synthesis of PEG based hydrogels having different properties was done by free radical photopolymerization by using a photoinitiator . In this stage because of their biocompatibility, poly ethylene glycol Diacrylate (PEG-DA) as macromer; ethylene glycol dimetacrylate (EGDMA) as cross-linker and 2,2 dimetoxy-2 phenylacetophenon (DMPA) as photoinitiator were used. The macromer amounts of 30, 50 and 100%, cross-linker ratio of 0.25, 1.0 and 3% and photoinitiator ratio of 0.1, 0.5 and 1% by weight were selected. In this scope, dynamic swelling behaviour of hydrogels and their suitability for controlled drug release were tested. The surface characterization of the hydrogels was performed by Attenuated Total Reflectance-Fourier Transfer Infrared Spectroscopy (ATR-FTIR) spectrums. The drug release experiments of dry polymer disks with known weight and known loaded drug amount were performed in pH 7.4 and 1.2 buffer solutions with set ionic strengths, in shaking incubator at 37°C constant temperature with a shaking speed of 100 rpm. In the last part of the work, drug activities of synthesized drug-loaded hydrogels were tested in Staphylococcus aureus and Pseudomonas aeruginosa bacteria cultures. Results: A decrease in swelling degree of hydrogel was observed with an increase in macromer ratio. In the ATR-FTIR spectrums, O-H tension, C-H tension, C=O tension, C-O tension vibration bands which can be said to be a characteristic of PEG-DA hydrogels were observed. The rate of drug release in pH 1.2 was observed to be much faster than pH 7.4 for both types of hydrogels. The transport mechanism in hydrogels was determined by a widely used semi-empirical formula. It was observed that selected drug-loaded hydrogels were effective on inhibition of the reproduction of both bacteria. Conclusion: In the work presented, all of the hydrogels synthesized were found compatible for the controlled drug delivery. Key Words: Photopolymerization, hydogels, controlled drug delivery; PEG. Conflict of Interest:The authors declare no conflict of interest. ÖZETAmaç: Sunulan araştırma kapsamında; PEG bazlı hidrojellerin sentezi, elde edilen hidrojellerin karakterizasyonu ve bu hidrojellerin kontrollü ilaç salım sistemlerinde kullanımlarının incelenmesi amaçlanmıştır. Metod: Farklı özelliklere sahip PEG bazlı hidrojellerin fotopolimerizasyon yöntemi ile fotobaşlatıcı kullanılarak serbest-radikal fotopolimerizasyonuyla sentezi gerçekleştirilmiştir. Bu aşamada yüksek biyouyumluluğu nedeniyle poli(etilenglikol) diakrilat (PEGDA) makromeri; çapraz bağlayıcı olarak etilen glikol dimetakrilat (EGDMA), fotobaşlatıcı olarak ise 2,2-dimetoksi-2-fenilasetofenon (DMPA) kullanılmıştır. Makromer oranı ağırlıkça %30, 50 ve 100; çapraz bağlayıcı oranı ağırlıkça %0.25, 1.0, 3.0; fotobaşlatıcı oranı ağırlıkça %0.1, 0.5 ve 1 değerlerinde değiştirilerek bileşen mikt...

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Design of a novel hydrogel-based intelligent system for controlled drug release

Cited by 175 publications

References 26 publications

Controlled release and interaction of protein using self‐assembling peptide RATEA16 nanofiber hydrogels

Controlled release and interaction of protein using self‐assembling peptide RATEA16 nanofiber hydrogels

Buccal Drug Delivery System : History and Recent Developments

Photocrosslinked Poly(Ethylen Glycol) Hydrogels for Controlled Drug Delivery

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