Design of a Patient-Specific Radiotherapy Treatment Target

Heyns, Michael; Breseman, Kelsey; Lee, Christopher; Bloch, B; Jaffe, C. Carl; Xiang, H

doi:10.1109/nebec.2013.75

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…The first version of the pelvis-base cartridge is a direct transition from a related design for holding TLDs [21][22] to one for radiochromic film. CAD renders are shown in Fig.…”

Section: Pelvis-base Cartridge Version 1: Film Holder Onlymentioning

confidence: 99%

A Three-Dimensional-Printed Patient-Specific Phantom for External Beam Radiation Therapy of Prostate Cancer

Lee

Dietrich

Desai

et al. 2018

Journal of Engineering and Science in Medical Diagnostics and Therapy

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This paper presents the design evolution, fabrication, and testing of a novel patient and organ-specific, three-dimensional (3D)-printed phantom for external beam radiation therapy (EBRT) of prostate cancer. In contrast to those found in current practice, this phantom can be used to plan and validate treatment tailored to an individual patient. It contains a model of the prostate gland with a dominant intraprostatic lesion (DIL), seminal vesicles, urethra, ejaculatory duct, neurovascular bundles, rectal wall, and penile bulb generated from a series of combined T2-weighted/dynamic contrast-enhanced magnetic resonance (MR) images. The iterative process for designing the phantom based on user interaction and evaluation is described. Using the CyberKnife System at Boston Medical Center, a treatment plan was successfully created and delivered. Dosage delivery results were validated through gamma index calculations based on radiochromic film measurements which yielded a 99.8% passing rate. This phantom is a demonstration of a methodology for incorporating high-contrast MR imaging into computed-tomography-based radiotherapy treatment planning; moreover, it can be used to perform quality assurance (QA).

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“…The first version of the pelvis-base cartridge is a direct transition from a related design for holding TLDs [21][22] to one for radiochromic film. CAD renders are shown in Fig.…”

Section: Pelvis-base Cartridge Version 1: Film Holder Onlymentioning

confidence: 99%

A Three-Dimensional-Printed Patient-Specific Phantom for External Beam Radiation Therapy of Prostate Cancer

Lee

Dietrich

Desai

et al. 2018

Journal of Engineering and Science in Medical Diagnostics and Therapy

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show abstract

“…In particular, treatment of the scarp in brain, MRM in breast, patient organ-shaped phantom and dedicated phantom for evaluation of medical imaging were developed in the field of radiation therapy and medical physics. [9][10][11][12][13][14] Kim et al 11) analyzed dosimetric parame- ters of the 3D printed customized bolus, and reported that it provided a good dose escalation and contact with the irregular surface of the RANDO phantom.…”

Section: Introductionmentioning

confidence: 99%

Customized 3D Printed Bolus for Breast Reconstruction for Modified Radical Mastectomy (MRM)

Jung

Kim

et al. 2016

Prog Med Phys

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We aim to develop the breast bolus by using a 3D printer to minimize the air-gap, and compare it to commercial bolus used for patients undergoing reconstruction in breast cancer. The bolus-shaped region of interests (ROIs) were contoured at the surface of the intensity-modulated radiation therapy (IMRT) thorax phantom with 5 mm thickness, after which the digital imaging and communications in mdicine (DICOM)-RT structure file was acquired. The intensity-modulated radiation therapy (Tomo-IMRT) and direct mode (Tomo-Direct) using the Tomotherapy were established. The 13 point doses were measured by optically stimulated luminescence (OSLD) dosimetry. The measurement data was analyzed to quantitatively evaluate the applicability of 3D bolus. The percentage change of mean measured dose between the commercial bolus and 3D-bolus was 2.3% and 0.7% for the Tomo-direct and Tomo-IMRT, respectively. For air-gap, range of the commercial bolus was from 0.8 cm to 1.5 cm at the periphery of the right breast. In contrast, the 3D-bolus have occurred the air-gap (i.e., 0 cm). The 3D-bolus for radiation therapy reduces the air-gap on irregular body surface that believed to help in accurate and precise radiation therapy due to better property of adhesion.

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Characterization of 3D printing techniques: Toward patient specific quality assurance spine-shaped phantom for stereotactic body radiation therapy

Kim

Lee

et al. 2017

PLoS ONE

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Development and comparison of spine-shaped phantoms generated by two different 3D-printing technologies, digital light processing (DLP) and Polyjet has been purposed to utilize in patient-specific quality assurance (QA) of stereotactic body radiation treatment. The developed 3D-printed spine QA phantom consisted of an acrylic body phantom and a 3D-printed spine shaped object. DLP and Polyjet 3D printers using a high-density acrylic polymer were employed to produce spine-shaped phantoms based on CT images. Image fusion was performed to evaluate the reproducibility of our phantom, and the Hounsfield units (HUs) were measured based on each CT image. Two different intensity-modulated radiotherapy plans based on both CT phantom image sets from the two printed spine-shaped phantoms with acrylic body phantoms were designed to deliver 16 Gy dose to the planning target volume (PTV) and were compared for target coverage and normal organ-sparing. Image fusion demonstrated good reproducibility of the developed phantom. The HU values of the DLP- and Polyjet-printed spine vertebrae differed by 54.3 on average. The PTV Dmax dose for the DLP-generated phantom was about 1.488 Gy higher than that for the Polyjet-generated phantom. The organs at risk received a lower dose for the 3D printed spine-shaped phantom image using the DLP technique than for the phantom image using the Polyjet technique. Despite using the same material for printing the spine-shaped phantom, these phantoms generated by different 3D printing techniques, DLP and Polyjet, showed different HU values and these differently appearing HU values according to the printing technique could be an extra consideration for developing the 3D printed spine-shaped phantom depending on the patient’s age and the density of the spinal bone. Therefore, the 3D printing technique and materials should be carefully chosen by taking into account the condition of the patient in order to accurately produce 3D printed patient-specific QA phantom.

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Design of a Patient-Specific Radiotherapy Treatment Target

Cited by 3 publications

References 3 publications

A Three-Dimensional-Printed Patient-Specific Phantom for External Beam Radiation Therapy of Prostate Cancer

A Three-Dimensional-Printed Patient-Specific Phantom for External Beam Radiation Therapy of Prostate Cancer

Customized 3D Printed Bolus for Breast Reconstruction for Modified Radical Mastectomy (MRM)

Characterization of 3D printing techniques: Toward patient specific quality assurance spine-shaped phantom for stereotactic body radiation therapy

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