Design of a Potential Colonic Drug Delivery System of Mesalamine

Gohel, Mukesh C.; Parikh, Rajesh K.; Nagori, Stavan A.; Dabhi, Mahesh R.

doi:10.1080/10837450802088679

Cited by 10 publications

(15 citation statements)

References 32 publications

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“…The capsules were coated with Eudragit ® S100 solution to a level such that the drug release was prevented in media with pH 1.2 (mimicking fasting conditions of stomach) and pH 6.0 (mimicking fasting conditions of upper intestine). [15,20] A lag time of 30 minutes was desirable at pH 7.2 (mimicking fasting conditions of proximal ileum). [15] The Eudragit ® S100 coated capsules (batches A10-A12) were characterized for enteric test and in vitro drug release.…”

Section: Formulationmentioning

confidence: 99%

“…[15,20] A lag time of 30 minutes was desirable at pH 7.2 (mimicking fasting conditions of proximal ileum). [15] The Eudragit ® S100 coated capsules (batches A10-A12) were characterized for enteric test and in vitro drug release.…”

Section: Formulationmentioning

confidence: 99%

“…[15] The formulation was prepared using eutectic mixture of ibuprofen and menthol to uniformly distribute the drug in the dosage form and surpass existing patents on colonic drug delivery systems of ibuprofen. [16] In addition, menthol is a well known intestinal and dermal permeation enhancer [17,18] and anti-tumor agent.…”

Section: C Gohel S a Nagorimentioning

confidence: 99%

“…The percentage weight gain of ethyl cellulose was varied from 1.5-3% (batches A6-A9) to get the desired in vitro lag time of 90 minutes in phosphate buffer with pH 7.2 (mimicking fasting conditions of terminal ileum). [15] The capsules of batch A9 were filled in another HPMC capsule (size 00). The capsules were coated with Eudragit ® S100 solution to a level such that the drug release was prevented in media with pH 1.2 (mimicking fasting conditions of stomach) and pH 6.0 (mimicking fasting conditions of upper intestine).…”

Section: Formulationmentioning

confidence: 99%

“…Ibuprofen capsules (size 0) containing adsorbate of eutectic mixture of ibuprofen and menthol and pregelatinized starch were over-coated with a semipermeable polymer (ethyl cellulose) to provide a lag time of 90 min at pH 7.2 (mimicking transition time of solid dosage form from terminal ileum to ascending colon). [15] The ethyl cellulose coated capsules were then filled into another capsule (size 00) and the capsules were coated with an enteric polymer (Eudragit ® S100) to a level such that a lag time of 30 minutes at pH 7.2 (mimicking transition time of solid dosage form from proximal A novel colonic drug delivery system of ibuprofen…”

Section: Introductionmentioning

confidence: 99%

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A novel colonic drug delivery system of ibuprofen

Gohel¹,

Nagori²

2009

Asian J Pharm

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T he present endeavor was directed towards fabrication of the novel colonic drug delivery system of ibuprofen. To begin with, the hydroxypropyl methylcellulose capsules containing adsorbate of eutectic mixture of ibuprofen and menthol and pregelatinized starch were coated with ethyl cellulose. These ethyl cellulose coated capsules were filled in another capsule and the capsules were coated with a Eudragit ® S100. The in vitro drug release study was conducted using sequential dissolution technique at pH 1.2 (two hour), 6.0 (1hr), 7.2 (two hour) and 6.4 (three hour) mimicking different regions of gastrointestinal tract. The optimized batch with two per cent and 6.5% weight gain of ethyl cellulose and Eudragit ® S100 showed less than eight per cent drug release in stomach and intestinal pH. The remaining 92% drug release was obtained thereafter from the optimized batch within two hours in colonic pH. Scanning electron microscopy study of the optimized batch confirmed presence of ibuprofen crystals (rod shape) in the formulation. The infrared spectroscopy study of the optimized batch indicated stability of ibuprofen during processing of the formulation.

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Section: Formulationmentioning

confidence: 99%

Section: Formulationmentioning

confidence: 99%