Design of a rapid electrochemical biosensor based on MXene/Pt/C nanocomposite and DNA/RNA hybridization for the detection of COVID-19

Recent advances using MXenes in biomedical applications

“…In general, gold nanoparticles are incorporated, especially for the conjugation of DNA probes. [144][145][146][147][148] The sensing range for miRNA, [144][145][146] DNA/RNA, 147,149 or genes 148 is lower than BnM. For the sensing of proteins (e.g., cTnI, 150,151 H5N1 viral proteins, 152 IL-6 153,154 or Sortase A 142 ), detection limits reach as low as Bfg mL À1 .…”

“…195 Electrochemical sensors for microorganisms using MXene-based nanomaterials are summarized in Table 4. Exosomes, [196][197][198][199] bacteria, [200][201][202][203][204][205] viruses, 149,[206][207][208][209] and even cancer cells 114,171 can be measured through appropriate surface modification of electrodes. The lowest sensing range is about 10 particles per mL.…”

“…In general, gold nanoparticles are incorporated, especially for the conjugation of DNA probes. 144–148 The sensing range for miRNA, 144–146 DNA/RNA, 147,149 or genes 148 is lower than ∼nM. For the sensing of proteins ( e.g.…”

Revolutionizing Infection Control: Harnessing MXene‐Based Nanostructures for Versatile Antimicrobial Strategies and Healthcare Advancements

“…When tested with clinical samples, it achieved 100 % accuracy and sensitivity, 97.87 % specificity, and a limit of quantification (LOQ) of 60 copies/mL. [110] To detect Hepatitis B virus (HBV) DNA, scientists developed a CRISPR-Cas12a-based colorimetric biosensor. [111] This biosensor employed Mxene-probe DNAÀ Ag/Pt nanohybrids, showing remarkable sensitivity and specificity with detection limits in the subpicomolar range.…”

“…The biosensor exhibited high sensitivity, boasting a low limit of detection (LOD) of 0.4 aM. When tested with clinical samples, it achieved 100 % accuracy and sensitivity, 97.87 % specificity, and a limit of quantification (LOQ) of 60 copies/mL [110] …”