Design of a self-unfolding delivery concept for oral administration of macromolecules

Abstract

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In Vitro Interaction of Doxorubicin-Loaded Silk Sericin Nanocarriers with MCF-7 Breast Cancer Cells Leads to DNA Damage

“…Photopolymerization of various monomers in the presence of photocatalytic doxorubicin hydrochloride proved an interesting method to prepare drug-loaded polymeric nanoparticles with higher polymerization rates and good doxorubicin encapsulation efficiency [ 41 ]. Protein nanoparticles were also prepared by various routes to easily entrap and release various anticancer drugs [ 43 ]. They are prepared within biological systems, require fewer production steps, and show high biocompatibility and biodegradability, as compared to synthetic polymers.…”

Administration strategies and smart devices for drug release in specific sites of the upper GI tract

“…Indeed, this region has broadly been described for the increased chances of absorption if compared with the small bowel, in view of the relatively long transit time, the lower concentration of proteolytic enzymes in the lumen, the brush-border membrane and the higher responsiveness of the mucosa to permeation enhancers. More recently, systems able to develop a high surface in close contact with the small intestine epithelium, thus creating a local environment of high concentration and reducing the chance of macromolecule degradation into the lumen, have also been proposed [72]. However, besides entailing the development of broadly new drug-containing formulations, these approaches were generally characterized by reduced bioavailability compared with dosing via the parenteral routes.…”

pH-Responsive and Mucoadhesive Nanoparticles for Enhanced Oral Insulin Delivery: The Effect of Hyaluronic Acid with Different Molecular Weights

“…With the continuous development of nanotechnology, there are many countermeasures to improve the bioavailability of oral INS [ 7 , 8 ]. pH-responsive delivery systems are the most widely reported INS carriers for targeted delivery and controlled release [ 9 , 10 , 11 , 12 , 13 ].…”