Robot-assisted cooperative rehabilitation training has shown superiority in helping the individuals with motion impairment problems to regain their motor functions. This paper presents the development and evaluation of a new cooperative training control scheme for an end-effector-type rehabilitation robot to provide upper extremity rehabilitation training with desired compliance and intensity. Firstly, the overall mechanical structure and real-time control system of rehabilitation robot are introduced. Secondly, an integral fuzzy sliding mode impedance control strategy combined with time-delay estimation (IFSMIC-TDE) is proposed to induce the active participation of patients and suppress impedance error. The IFSMIC-TDE approach is free from nonlinear robot dynamics, and it is designed to be robust to the external uncertainties and inherent chattering characteristics. After that, the closed-loop system stability with IFSMIC-TDE is proved based on the Lyapunov stability theory. Finally, experimental investigations are conducted to illustrate the effectiveness of the proposed rehabilitation robot and control algorithm. The comparison results indicate that the proposed IFSMIC-TDE can achieve better control performance and less impedance error. Besides, the interaction compliance and training intensity can be qualitatively adjusted via appropriate impedance parameters. INDEX TERMS Upper extremity rehabilitation robot, cooperative training, sliding mode impedance control, fuzzy turner, time delay estimation.