Design of an Electrochemical Sensor for the Determination of Riboflavin using Cobalt Doped Dysprosium Oxide Nanocubes Modified Glassy Carbon Electrode

Abstract

This study explains the synthesis of cobalt‐doped dysprosium oxide nanocubes (Co‐Dy2O3 NCs) and the modification of GCE (glassy carbon electrode), for the selective and sensitive detection of riboflavin (RF). The Co‐Dy2O3 NCs were synthesized by co‐precipitation method and characterized using spectroscopic and microscopic techniques like micro‐Raman Spectroscopy, X‐ray diffraction (XRD), X‐ray Photoelectron Spectroscopy (XPS), Fourier Transform Infrared Spectroscopy (FT‐IR), High‐Resolution Transmission Electron Microscopy (HRTEM), Energy‐Dispersive X‐ray Spectroscopy (EDX), and High Resolution Scanning Electron Microscopy (HRSEM). The synthesized Co‐Dy2O3 NCs were coated on the glassy carbon electrode to detect and quantify the concentration of riboflavin in aqueous and real samples. The samples were analyzed by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques with three‐electrode system. The modified electrode displays two linear concentration ranges (0.5–50, 50–300 μM) with a low detection limit (LOD) of 0.094 μM and high sensitivity of 3.67 μA μM−1 cm−2. Besides, the fabricated sensor has more selectivity, great reproducibility, repeatability and good stability. Finally, the Co‐Dy2O3 NCs modified GCE based sensor was effectively applied in real sample analysis using milk and egg yolk with good recovery.

Water-Soluble Photoluminescent Adenosine-Functionalized Gold Nanoclusters as Highly Sensitive and Selective Receptors for Riboflavin Detection in Rat Brain

“…The linear ranges and the limit of detection are 0.005–0.1 and 0.002 nM, respectively. To the best of our knowledge, the LOD value for RF is far superior to those values given from other methods. − ,− The selectivity of the photoluminescence sensor is challenged by some potentially interfering substances that possibly exist in the rat brain, such as metal ions, anions, amino acids, glucose, nicotinamide, uric acid, ascorbic acid, folic acid, dopamine, glutathione (GSH), bovine serum albumin (BSA), or hydrogen peroxide (H 2 O 2 ). The photoluminescence spectra of Ade-AuNCs without and with RF (0.05 nM) or each interferent (0.05 nM) are displayed in Figure A, and the selectivity plot is shown in Figure B–E.…”

“…Up to now, several methods have been developed for in vitro riboflavin detection, including high-performance liquid chromatography, 5 voltammetry, 6 spectrophotometry, 7 and fluorimetry. 8 However, it is difficult to apply these methods for fast, selective, and sensitive detection of cerebral riboflavin due to the intrinsic high chemical complexity of the cerebral system.…”

Electrochemical sensing of B-complex vitamins: current challenges and future prospects with microfluidic integration

“…The modied electrode has two linear concentration ranges (0.5-50, 50-300 mM) with a low LOD of 0.094 mM and a high sensitivity of 3.67 mA mM −1 cm −2 . 60 Vitamin B6 was measured using square wave voltammetry (SWV) at a copper-poly(1,8-diaminonaphthalene)/graphene-modied GCE by Vu et al 61 In their study (Fig. 4B), a novel approach was employed to construct a copper-poly(1,8diaminonaphthalene)/graphene composite lm with the purpose of electrochemically detecting VB6.…”

Construction of Cu2O−Ag Nanocomposites for the Selective and Efficient Electrochemical Detection of Catechol

“…Precise analytical methods such as HPLC, flow‐injection, fluorescence, and electrochemical techniques have been applied for the detection of CC [9–12] . Among these techniques, the electrochemical method has drawn much attention due to its easy handling and quick response to the monitoring of environmental compounds [13–15] …”

“…[9][10][11][12] Among these techniques, the electrochemical method has drawn much attention due to its easy handling and quick response to the monitoring of environmental compounds. [13][14][15] The performance of an electrochemical sensor strongly depends on the catalytic activity of the electrode materials. [16] The controllable integration of metals and metal oxides as metal-semiconductor heterostructures has attracted enormous attention in the field of catalysis because they not only inherit the distinguished properties of both metals and semiconductors but also have a synergistic effect in comparison with a single component.…”