Looking at the waste heat potential made available by industry, it can be noted that there are many sectors where small scale (< 100 kWe) organic Rankine cycle (ORC) plants could be applied to improve the energy efficiency. Such plants are quite challenging from the techno-economic point of view: the temperature of the primary heat source poses a low cutoff to the system thermodynamic efficiency. Therefore, high-performance components are needed, but, at the same time, they have to be at low cost as possible to assure a reasonable payback time. In this paper, the design of a two-stage radial in-flow turbine for small ORC industrial plants is presented. Compared to commonly applied mono-stage expanders (both volumetric and dynamic), this novel turbine enables plants to exploit higher pressure ratios than conventional plants. Thus, the theoretical limit to the cycle efficiency is enhanced with undoubted benefits on the overall ORC plant performance. The design process involved 1D/2D models as well as 3D Computational Fluid Dynamic ones. After the design of the preliminary configuration, sensitivity analyses were carried out varying the most relevant geometric parameters for design performance improvement. Thereafter, the stages were both analyzed in off-design conditions giving their performance maps. Moreover, a stage stacking procedure was applied to obtain the overall turbine behavior.