Lateral load-deflection behaviour of single piles is often analysed in practice on the basis of methods of load-transfer P-Y curves. The paper is aimed at presenting the results of the interpretation of five full-scale horizontal loading tests of single instrumented piles in two sandy soils, in order to define the parameters of P-Y curves, namely the initial lateral reaction modulus and the lateral soil resistance, in correlation with the pressuremeter test parameters. P-Y curve parameters were found varying as a power of lateral pile/soil stiffness, on the basis of which hyperbolic P-Y curves in sand were proposed. The predictive capabilities of the proposed P-Y curves were assessed by predicting the soil/pile response in full-scale tests as well as in centrifuge tests and a very good agreement was found between the computed deflections and bending moments, and the measured ones. Small-sized database of fullscale pile loading tests in sand was built and a comparative study of some commonly used P-Y curve methods was undertaken. Moreover, it was shown that the load-deflection curves of these test piles may be normalised in a practical form for an approximate evaluation of pile deflection in a preliminary stage of pile design. At last, a parametric study undertaken on the basis of the proposed P-Y curves showed the significant influence of the lateral pile/soil stiffness on the nonlinear load-deflection response. Keywords Lateral loading test AE Lateral reaction modulus AE P-Y curves AE Pressuremeter test AE Sand AE Single pile List of symbols and units B diameter or frontal width of the pile (m) D embedded length of the pile (m) D e effective pile length (m) E elastic soil modulus (MPa) e excentricity of lateral load (m) E c characteristic soil modulus (MPa) E m first load pressuremeter modulus (MPa) E r reload pressuremeter modulus (MPa) E ti initial lateral reaction modulus (MPa) E p I p flexural pile stiffness (MN m 2 ) F tangential lateral reaction (kN/m) F l limit tangential lateral reaction or tangential lateral resistance (kN/m) G r pressuremeter shear modulus (G r = E r / [2(1 + m)]) (MPa) H lateral load applied on the pile top (kN) I d density index (%) K pile/soil compressibility K r lateral pile/soil stiffness L tangential dimension of the pile section (parallel to H) (m)