Design of Bioartificial Pancreases From the Standpoint of Oxygen Supply

Iwata, Hiroo; Arima, Yusuke; Yusuke, Tsutsui

doi:10.1111/aor.13106

Cited by 25 publications

(24 citation statements)

References 31 publications

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“…Iwata et al. focused on the oxygen diffusion in a device and indicated that spherical bioartificial pancreas allows for selecting a wider range of membrane thicknesses than cylindrical and planar ones [14]. We didn't find any central necrosis, one sign of hypoxia, in the encapsulated spheroids, suggesting that a minimal oxygen concentration was maintained.…”

Section: Discussionmentioning

confidence: 64%

The intraperitoneal space is more favorable than the subcutaneous one for transplanting alginate fiber containing iPS-derived islet-like cells

Fukuda

Yabe

Nishida

et al. 2019

Regenerative Therapy

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Introduction Although immunosuppressants are required for current islet transplantation for type 1 diabetic patients, many papers have already reported encapsulation devices for islets to avoid immunological attack. The aim of this study is to determine the optimal number of cells and optimal transplantation site for human iPS-derived islet-like cells encapsulated in alginate fiber using diabetic model mice. Methods We used a suspension culture system for inducing islet-like cells from human iPS cells throughout the islet differentiation process. Islet-like spheroids were encapsulated in the alginate fiber, and cell transplantation experiments were performed with STZ-induced diabetic NOD/SCID mice. We compared the efficacy of transplanted cells between intraperitoneal and subcutaneous administration of alginate fibers by measuring blood glucose and human C-peptide levels serially in mice. Grafts were analyzed histologically, and gene expression in pancreatic β cells was also compared. Results We demonstrated the reversal of hyperglycemia in diabetic model mice after intraperitoneal administration of these fibers, but not with subcutaneous ones. Intraperitoneal fibers were easily retrieved without any adhesion. Although we detected human c-peptide in mice plasma after subcutaneous administration of these fibers, these fibers became encased by fibrous tissue. Conclusions These results suggest that the intraperitoneal space is favorable for islet-like cells derived from human iPS cells when encapsulated in alginate fiber.

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Section: Discussionmentioning

confidence: 64%

The intraperitoneal space is more favorable than the subcutaneous one for transplanting alginate fiber containing iPS-derived islet-like cells

Fukuda

Yabe

Nishida

et al. 2019

Regenerative Therapy

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show abstract

“…Spherical microcapsules, for example, typically feature diameters ranging from 250 μm to 1500 μm [16,254,297]; however, theoretical analyses of physiological oxygen transport suggest that the thickness of a spherical microcapsule should be controlled below 100 μm to avoid central islet hypoxia and necrosis in common transplantation sites [298]. Buchwald et al also demonstrated that 1800 μm-diameter microspheres delay and reduce insulin secretion as a result of the large distance which must be traversed by passive diffusion [129].…”

Section: Nanoencapsulationmentioning

confidence: 99%

Nanotechnology in cell replacement therapies for type 1 diabetes

Ernst

Bowers

Wang

et al. 2019

Advanced Drug Delivery Reviews

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Islet transplantation is a promising long-term, compliance-free, complication-preventing treatment for type 1 diabetes. However, islet transplantation is currently limited to a narrow set of patients due to the shortage of donor islets and side effects from immunosuppression. Encapsulating cells in an immunoisolating membrane can allow for their transplantation without the need for immunosuppression. Alternatively, "open" systems may improve islet health and function by allowing vascular ingrowth at clinically attractive sites. Many processes that enable graft success in both approaches occur at the nanoscale level-in this review we thus consider nanotechnology in cell replacement therapies for type 1 diabetes. A variety of biomaterial-based strategies at the nanometer range have emerged to promote immune-isolation or modulation, proangiogenic, or insulinotropic effects. Additionally, coating islets within nano-thin polymer films has burgeoned as an islet protection modality. Materials approaches that utilize nanoscale features manipulate biology at the molecular scale, offering unique solutions to the enduring challenges of islet transplantation.

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“…Hiroo Iwata et al of RIKEN, Kobe, Japan, reported on their continuing research on a bioartificial pancreas (BAP). They derived several equations considering oxygen supply in BAPs in order to provide insights into the rational design of three different types of BAPs (spherical microcapsules, cylindrical capsules, and planar capsules).…”

Section: Pancreatic Supportmentioning

confidence: 99%

Artificial Organs 2018: A Year in Review

Malchesky¹

2019

Artificial Organs

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In this Editor's Review, articles published in 2018 are organized by category and summarized. We provide a brief reflection of the research and progress in artificial organs intended to advance and better human life while providing insight for continued application of these technologies and methods. Artificial Organs continues in the original mission of its founders “to foster communications in the field of artificial organs on an international level.” Artificial Organs continues to publish developments and clinical applications of artificial organ technologies in this broad and expanding field of organ Replacement, Recovery, and Regeneration from all over the world. Peer‐reviewed special issues this year included contributions from the 13th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion edited by Dr. Akif Undar, and the 25th Congress of the International Society for Mechanical Circulatory Support edited by Dr. Marvin Slepian. Additionally, many editorials highlighted the worldwide survival differences in hemodialysis and perspectives on mechanical circulatory support and stem cell therapies for cardiac support. We take this time also to express our gratitude to our authors for offering their work to this journal. We offer our very special thanks to our reviewers who give so generously of time and expertise to review, critique, and especially provide meaningful suggestions to the author's work whether eventually accepted or rejected. Without these excellent and dedicated reviewers the quality expected from such a journal could not be possible. We also express our special thanks to our Publisher, John Wiley & Sons for their expert attention and support in the production and marketing of Artificial Organs. We look forward to reporting further advances in the coming years.

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Design of Bioartificial Pancreases From the Standpoint of Oxygen Supply

Cited by 25 publications

References 31 publications

The intraperitoneal space is more favorable than the subcutaneous one for transplanting alginate fiber containing iPS-derived islet-like cells

The intraperitoneal space is more favorable than the subcutaneous one for transplanting alginate fiber containing iPS-derived islet-like cells

Nanotechnology in cell replacement therapies for type 1 diabetes

Artificial Organs 2018: A Year in Review

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