Design of biocompatible and self-antibacterial titanium surfaces for biomedical applications

Pandey, Lalit M.

doi:10.1016/j.cobme.2022.100423

Cited by 19 publications

(10 citation statements)

References 36 publications

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“…Silane or thoil reagents are used for this purpose. For example, 3-aminopropyltriethoxysilane (APTES) and octadecyltriethoxysilane (OTES) provide -NH 2 and -COOH groups, respectively, on surfaces [ 166 , 167 , 168 ]. Ligands can be directly attached to surfaces with SAMs.…”

Section: Detection Methods For Exosomesmentioning

confidence: 99%

Biogenesis, Isolation, and Detection of Exosomes and Their Potential in Therapeutics and Diagnostics

2023

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The increasing research and rapid developments in the field of exosomes provide insights into their role and significance in human health. Exosomes derived from various sources, such as mesenchymal stem cells, cardiac cells, and tumor cells, to name a few, can be potential therapeutic agents for the treatment of diseases and could also serve as biomarkers for the early detection of diseases. Cellular components of exosomes, several proteins, lipids, and miRNAs hold promise as novel biomarkers for the detection of various diseases. The structure of exosomes enables them as drug delivery vehicles. Since exosomes exhibit potential therapeutic applications, their efficient isolation from complex biological/clinical samples and precise real-time analysis becomes significant. With the advent of microfluidics, nano-biosensors are being designed to capture exosomes efficiently and rapidly. Herein, we have summarized the history, biogenesis, characteristics, functions, and applications of exosomes, along with the isolation, detection, and quantification techniques. The implications of surface modifications to enhance specificity have been outlined. The review also sheds light on the engineered nanoplatforms being developed for exosome detection and capture.

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Section: Detection Methods For Exosomesmentioning

confidence: 99%

Biogenesis, Isolation, and Detection of Exosomes and Their Potential in Therapeutics and Diagnostics

2023

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“…The ideal scenario, notwithstanding the encouraging results would be for the materials to directly display bactericidal activity through their components without obstructing bone formation and osseointegration, as was the case for Ti-Cu and TiAg alloys. However, the creation of surfaces that can lessen bacterial adherence and kill germs locally by contact without releasing any material is a promising method to get around toxicity issues [210,211].…”

Section: Listparagraph4listparagraph Surface Modification Of Ti Alloy...mentioning

confidence: 99%

A review—metastable β titanium alloy for biomedical applications

Pesode

2023

J. Eng. Appl. Sci.

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Titanium and its alloys have already been widely used as implant materials due to their outstanding mechanical characteristics and biocompatibility. Notwithstanding this, researchers and businesses alike have continued to actively pursue superior alloys since there are still problems which need urgent consideration. One of these is a noteworthy difference in the implant material’s elastics modulus and that of natural bone, which result into an issue of stress shielding. With prolonged use Ti alloys releases dangerous ions. The Ti alloy surface has a low bioactivity, which prolongs the healing process. β-Ti alloys could be used as viable alternatives when creating dental implants. Additionally, β-Ti alloys characteristics, such as low Young modulus, increased strength, appropriate biocompatibility, and strong abrasion and corrosion resistance, serve as the necessary evidence. Ti alloys when altered structurally, chemically, and by thermomechanical treatment thereby enabling the creation of material which can match the requirements of a various clinical practise scenarios. Additional research is needed which can focused on identifying next century Ti alloys consisting of some more compatible phase and transforming the Ti alloys surface from intrinsically bioinert to bioactive to prevent different issues. In order to give scientific support for adopting β-Ti-based alloys as an alternative to cpTi, this paper evaluates the information currently available on the chemical, mechanical, biological, and electrochemical properties of key β-titanium alloys designed from the past few years. This article is also focusing on β-titanium alloy, its properties and performance over other type of titanium alloy such as α titanium alloys. However, in-vivo research is needed to evaluate novel β titanium alloys to support their use as cpTi alternatives.

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“…Biomedical implants are great creations in human medical history, which are widely used to save countless people from the pain of tissue loss and necrosis, especially in the restoration of hard tissues. − The application of suitable materials with good biocompatibility, matching mechanical properties, and stability is the key to developing implants. − To data, there are three typical implants in clinical applications, including stainless steel, cobalt–chromium alloy, and Ti based alloy. − As shown in Figure , the mechanical properties of medical stainless steel are quite different from those of hard tissue, making it is easy to cause implant failure. − Cobalt-based medical metal materials have excellent mechanical properties, wear resistance, and corrosion resistance, but the release of cobalt, nickel, and other metal ions in the constituent elements easily causes cell and tissue necrosis . Due to the best biocompatibility, matching mechanical properties, and good corrosion resistance, Ti alloys are recognized as the most suitable implant material. , …”

Section: Introductionmentioning

confidence: 99%

Surface Modification and Functionalities for Titanium Dental Implants

Sun,

Liu,

Wang

et al. 2023

ACS Biomater. Sci. Eng.

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Dental implants have become the mainstream strategy for oral restoration, and implant materials are the most important research hot spot in this field. So far, Ti implants dominate all kinds of implants. The surface properties of the Ti implant play decisive roles in osseointegration and antibacterial performance. Surface modifications can significantly change the surface micro/nanotopography and composition of Ti implants, which will effectively improve their hydrophilicity, mechanical properties, osseointegration performance, antibacterial performance, etc. These optimizations will thus improve implant success and service life. In this paper, the latest surface modification techniques of Ti dental implants are systematically and comprehensively reviewed. The various biomedical functionalities of surface modifications are discussed in-depth. Finally, a profound comment on the challenges and opportunities of this frontier is proposed, and the most promising directions for the future were explored.

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Design of biocompatible and self-antibacterial titanium surfaces for biomedical applications

Cited by 19 publications

References 36 publications

Biogenesis, Isolation, and Detection of Exosomes and Their Potential in Therapeutics and Diagnostics

Biogenesis, Isolation, and Detection of Exosomes and Their Potential in Therapeutics and Diagnostics

A review—metastable β titanium alloy for biomedical applications

Surface Modification and Functionalities for Titanium Dental Implants

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