Design of biocompatible polylactic acid–polyethylene glycol combination for manufacturing biodegradable staplers

Bakhtiary, Negar; Bagheri, Hamed; Salehnia, Mojdeh

doi:10.1002/app.54800

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…Stearic acid and oleic acid are widely found in plants and animals, serving as natural raw materials with a minimal environmental impact. PEG400MO, a polyethylene glycol polymer with a relative molecular mass of 400, is commonly used in the preparation of degradable compositions [38,39]. Cellulose, one of the most abundant renewable resources in nature, is utilized in various fields through its derivatives.…”

Section: Greenness Of Raw Materials For Preparation Of Tetramycin-loa...mentioning

confidence: 99%

Development of Tetramycin-Loaded Core–Shell Beads with Hot-/Wet-Responsive Release Properties for Control of Bacterial Wilt Disease

Gao,

Lin,

Deng

et al. 2024

Agronomy

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Plant bacterial wilt is caused by Ralstonia solanacearum, a soilborne pathogen that infects plant conduits, leading to wilt disease. It is extremely difficult to cure plants infected with Ralstonia solanacearum; however, bactericide-loaded beads with hot-/wet-responsive properties may be able to release a biocide in line with the increase in the hot-/wet-associated activity of Ralstonia solanacearum, effectively killing the pathogenic cells and providing high levels of plant protection. A biopesticide, Tetramycin, was embedded in corn kernel powder (CKP)-based cores. An oil-phase mixture was sprayed onto the core surface to form a hot-/wet-responsive intermediate shell (IMS). Subsequently, a layer of ethyl cellulose (EC) and hydroxypropyl methyl cellulose (HPMC) was coated onto the IMS to create a single wet-responsive outer shell (OTS). The ratios of the components in the cores, including the corn kernel powder (CKP), xanthan gum (XG), and Tetramycin, were optimized, as well as those of the IMS, including pentaerythrityl tetrastearate (PETS), pentaerythrityl tetraoleate (PETO), polyethylene glycol stearate (PEG400MS), and polyethylene glycol monooleate (PEG400MO), and those of the outer shell (OTS), including ethyl cellulose (EC) and hydroxypropyl methyl cellulose (HPMC). A texture performance analysis, differential scanning calorimetry (DSC) analysis, thermogravimetric analysis (TGA), temperature and humidity response performance tests, scanning electron microscope (SEM) observations, and a field effectiveness test were conducted to characterize the Tetramycin-loaded beads. The results indicated that the optimal formula for the bead cores comprised a mass ratio of CKP/Tetramycin solution/XG = 13.5:23:2. The preferred mass ratio for IMS was PETS/PETO/PEG400MO = 10:30:10, and the formula for the applicable OTS consisted of a mass ratio of EC/HPMC = 5:1. In soil with a temperature of 30–35 °C and humidity of 30%, the release period of the Tetramycin-loaded beads, with a cumulative release rate of over 95%, could last up to 35 days. Furthermore, the Tetramycin-loaded beads exhibited a gradual and multi-cyclic release process under alternating hot/wet and dry/cold environments. The relative preventive efficacy of 54.74% on tobacco was revealed at a field-testing scale. A significant reduction in the abundance of Ralstonia solanacearum was also observed under treatment with the Tetramycin-loaded beads. The early fungal community structure exhibited higher consistency compared to the control. However, in the later stage, the diversity differences between the soil layers were restored. In conclusion, Tetramycin-loaded beads that could effectively respond to temperature and humidity fluctuations were developed, resulting in enhanced disease prevention efficacy and offering broad prospects for the prevention and control of Ralstonia solanacearum in agricultural settings.

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Section: Greenness Of Raw Materials For Preparation Of Tetramycin-loa...mentioning

confidence: 99%

Development of Tetramycin-Loaded Core–Shell Beads with Hot-/Wet-Responsive Release Properties for Control of Bacterial Wilt Disease

Gao,

Lin,

Deng

et al. 2024

Agronomy

View full text Add to dashboard Cite

show abstract

“…Additionally, it enables the utilization of agricultural waste. PETO [28,29]. Stearic Acid and Oleic Acid are widely found in plants and animals, serving as natural raw materials that do not easily cause harm to the environment.…”

Section: The Raw Materials For the Preparation Of Tetramycin Core-she...mentioning

confidence: 99%

Development of Tetramycin-loaded Core-Shell Balls with Hot/Wet-Response Releasing Property for the Control of Bacterial Wilt Disease

Gao,

Lin,

Deng

et al. 2024

Preprint

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Ralstonia solanacearum is the pathogen responsible for Ralstonia solanacearum, which is soil-borne, infests plant conduits to cause disease.They are not easy to control and are harmful.Therefore the development of a controlled-release agent responsive to the pathogen's soil temperature and moisture conditions could aid in its control. Corn kernel powder is used as a carrier for Tetramycin biopesticide, with various compounds tested for bonding.They were then made by extrusion moulding.Temperature and wetness responsive components, including Pentaerythritol Tetrastearate, Pentaerythritol Tetraoleate, Polyethylene Glycol Stearate, and Polyethylene Glycol Monooleate,are compounded and coated onto Tetramycin cores to form an intermediate shell layer. Finally, Ethyl cellulose(EC)and Hydroxypropyl methyl cellulose(HPMC) are dissolved and sprayed onto the outermost layer to complete the pellet's shell layer.After the evaluation of texture performance test,DSC analysis,TG test,temperature and humidity response performance test, as well as pellet cross-section SEM observation, field effectiveness test, etc., the preferred formulations were screened.The results showed that the preferred Core formulation:Corn kernel powder:Tetramycin aqueous:Xanthan gum mass ratio=13.5:23:2; Intermediate Shell layer:PETS: PETO: PEG400MO mass ratio=10:30:10; and Outer Shell layer: Ethyl cellulose (EC):Hydroxypropyl methyl cellulose (HPMC) mass ratio=5:1.Under soil conditions of high incidence of Ralstonia solanacearum, i.e., sustained warmth (30-35℃) and high humidity (30% moisture content), the formulated pills showed a release rate of 95.18% to 96.24% over a period of 35 days. Moreover, they showed a stepwise cyclic release process under alternating warm and humid-dry and cold conditions.In field tests on tobacco, a relative preventive efficacy of 54.74% was achieved 106 days post-transplanting. Soil bacterial community structure analysis revealed a significant decrease (2.28-2.84 times) in the abundance of Solanaceae Raelia under Tetramycin pellet treatment compared to the control. Additionally, fungal community structure showed highter consistency initially across various soil depths, with diversity differences between soil layers reestablished later (106 days), while the predominant categories of bacteria and fungi remained unchanged.In this study, we successfully developed a nucleoshell-type slow-controlled release pill embedded with Tetramycin. This pill effectively responded to temperature and humidity changes, resulting in high efficacy in disease prevention.This development holds significant promise for effectively improving drug utilization and easing application challenges, offering broad prospects for Ralstonia solanacearum prevention and control in agriculture.

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Current status and future developments of biopolymer microspheres in the field of pharmaceutical preparation

Wu,

Wang

et al. 2024

Advances in Colloid and Interface Science

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Design of biocompatible polylactic acid–polyethylene glycol combination for manufacturing biodegradable staplers

Cited by 4 publications

References 31 publications

Development of Tetramycin-Loaded Core–Shell Beads with Hot-/Wet-Responsive Release Properties for Control of Bacterial Wilt Disease

Development of Tetramycin-Loaded Core–Shell Beads with Hot-/Wet-Responsive Release Properties for Control of Bacterial Wilt Disease

Development of Tetramycin-loaded Core-Shell Balls with Hot/Wet-Response Releasing Property for the Control of Bacterial Wilt Disease

Current status and future developments of biopolymer microspheres in the field of pharmaceutical preparation

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