Design of biomaterials through direct ring-opening metathesis polymerisation of functionalised cyclic alkenes

Kobayashi, Shū; Tanaka, Masaru

doi:10.1039/d3me00063j

Mol. Syst. Des. Eng.

2023

DOI: 10.1039/d3me00063j

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Design of biomaterials through direct ring-opening metathesis polymerisation of functionalised cyclic alkenes

Shū Kobayashi

Masaru Tanaka

Abstract: Ring-opening metathesis polymerisation (ROMP) has become a popular method for synthesising complex functional polymers owing to the high functional group tolerance of metathesis catalysts.

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Cited by 7 publications

References 327 publications

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Ascorbic Acid‐derived New Polymer Spheres via Ternary Copolymerization for Highly Effective Activation of B Cells

Han,

Li,

et al. 2024

Adv Funct Materials

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Lymphocytes are crucial to defend against harmful pathogens and sustain adaptive immunity. Developing immunomodulating materials to activate lymphocytes is imperative to induce effective and enduring immune responses. Here, a new polymer serving as a highly efficient activator of B cells is reported and corresponding polymer spheres are synthesized through a droplet‐assisted ternary copolymerization process of ascorbic acid, ethylenediamine, and glyoxal. In‐depth studies are conducted on the polymerization mechanisms and polymer spheres ranging from 250 to 1200 nm with various surface functional groups are synthesized. These prepared polymer materials exhibit remarkable immunomodulatory functions correlated to the polymer spheres' size and surface functional groups, and effective activations on B cells are observed in vivo and in vitro. Through cell phagocytosis experiments and RNA sequencing analysis, it is proposed that the selective phagocytosis of B cells and the presence of CD21 on the B cell membrane contribute to the activation of B cells. This work has extended the realm of immunological research from a unique perspective of chemical synthesis, further substantiating the fundamental research and application potential of designing immunomodulating polymers.

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Ascorbic Acid‐derived New Polymer Spheres via Ternary Copolymerization for Highly Effective Activation of B Cells

Han,

Li,

et al. 2024

Adv Funct Materials

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The synthesis of polymers with ultra‐high molecular weight by combining ROMP and acyclic metathesis reaction

Xie,

Zhou,

Zhu

et al. 2024

Journal of Polymer Science

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Ring opening metathesis polymerization (ROMP) is widely used to prepare functional materials with various topological structures. However, it is difficult to prepare polymers with ultra‐high molecular weight (UHMW) directly. We found a new method to prepare UHMW polymers by combining ROMP and acyclic metathesis reaction. First, monomer NB‐2OH was polymerized by ROMP with different feed ratio of NB‐2OH/G3, and obtained well‐defined polymers P(NB‐2OH)n (n = 50, 200, and 463). Then acyclic metathesis reaction was used to synthesize UHMW polymers. The results indicated that polymer P(NB‐2OH)z with higher molecular weight (Mw = 6067.3 kg mol−1) and narrower distribution (PDI = 1.58) could be obtained at 80°C for 5 min, when P(NB‐2OH)463 was used as raw material with H2SO4/G3 = 10/1. Compared with polymer P(NB‐2OH)1990 (Mw = 5343.1 kg mol−1, PDI = 1.61) prepared by ROMP directly, the new method tremendously shortens reaction time, lowers the requirement for the purity of monomer and produces UHMW polymers with narrower distribution. The compositions of prepared polymers were also confirmed clearly by post‐modification and 1H NMR characterization.

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Azobenzene-containing ionic metathesis copolymers: Composition, self-assembly and photoresponsive property

Yang,

Wang,

Huang

et al. 2024

Polymer

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Design of biomaterials through direct ring-opening metathesis polymerisation of functionalised cyclic alkenes

Abstract: Ring-opening metathesis polymerisation (ROMP) has become a popular method for synthesising complex functional polymers owing to the high functional group tolerance of metathesis catalysts.

Cited by 7 publications

References 327 publications

Ascorbic Acid‐derived New Polymer Spheres via Ternary Copolymerization for Highly Effective Activation of B Cells

Ascorbic Acid‐derived New Polymer Spheres via Ternary Copolymerization for Highly Effective Activation of B Cells

The synthesis of polymers with ultra‐high molecular weight by combining ROMP and acyclic metathesis reaction

Azobenzene-containing ionic metathesis copolymers: Composition, self-assembly and photoresponsive property

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