Design of bone-like continuous gradient porous scaffold based on triply periodic minimal surfaces

Fabrication of polycaprolactone/calcium phosphates hybrid scaffolds impregnated with plant extracts using 3D printing for potential bone regeneration

“…4 A and B show the scaffolds printed with the filaments without particles (A) and with calcium phosphate particles (B). Both types of scaffolds were printed in a TPMS Gyroid shape and show experimental porosity between 48 and 52% and the characteristic interconnected pores which promotes vascularization and are appropriate for tissue regeneration [ [30] , [31] , [32] ]. As the filament without particles is much more flexible, the appearance of the scaffold walls becomes smoother and less geometrically defined, while the scaffold printed with the filament with CP particles shows more roughness on the surface of the walls and a more defined geometrical shape.…”

3D Printed Pedicle Screws with Microarc Oxidation Ceramic Interfaces Enhance Osteointegration and Orthopedic Fixation Feasibility

“…Current Ti6Al4V implants have a dense, solid matrix that allows cells and tissues to extend only to the surface of the implant but not to grow into the implant, increasing the risk of fixation failure due to bone resorption and decreased bone density around the implant interfaces . Currently, there is a gowing demands for metallic load-bearing implants employed in the field of orthopedics, such as hip and knee joint replacements, vertebral body reconstruction, and orthodontics. , How to improve the adaptation of mechanical properties of orthopedics metallic implants to promote osteointegration is the key issue. , Previous studies have optimized the mechanical properties of Ti-based scaffolds via introducing porous structure and 3D printing methods. , SLM printing technique generates 3D constructs from molten metal powders, and micropores formed in the workpieces due to the gas trapping and incomplete remelting. − Therefore, SLM-printed implants have a lower Young’s modulus than conventional orthopedic implants produced by direct machining of alloy rods. , In this study, the pedicle screws were designed to be fully through-hole and were fabricated by SLM 3D printing to improve cell ingrowth and accelerate osseointegration . This work also paves a new method for the development of high-performance orthopedic surgery implants.…”

Guidelines derived from biomineralized tissues for design and construction of high-performance biomimetic materials: from weak to strong

“…In terms of structural gradients, efforts have been devoted to designing and preparing gradient porous structures (gradients in pore size and porosity) similar to those found in bone. 461,[464][465][466][467][468][469] Bone possesses a radial gradient porous structure with a high internal porosity to reduce weight and facilitate nutrient transport, and a low external porosity to carry loads, and thus integrate conflicted properties. In addition, the gradient porous structure enables the smooth transition from the outer layer to the internal layer, and the stress can gradually change in the gradient structure.…”