Design of cefaclor monohydrate containing nanoparticles with extended antibacterial effect by Nano-Spray dryer: A Nanoenglobing study

Abstract

Spray drying is an important method used in pharmaceutical product manufacturing for many years. The nano-spray dryer developed in recent years provides ultrafine powders at nanoscale and high product yields. In this study, which was aimed at prolonged release in oral use, nanoparticles-(NPs) were obtained by nanoenglobation of cefaclor monohydrate-(CEF) with Eudragit RS 100-(ERS) with the help of nano-spray drying method. The particle size (PS) of the blank formulation was 186 nm whereas PSs of CEF containing NPs were between 328 and 389 nm. The average PDI of all NP formulations were below 0.4 and all prepared NPs had a positive ZP value. The encapsulation efficiency values were a range of 78-84 %. In vitro release studies of NPs showed extended-release up to 24 hours after the first 3 hours of burst effect. The results showed that the release kinetics were fitted to the Korsmeyer-Peppas model. As a result, it was found that all pharmaceutical technology analysis results were affected by the solid concentration ratio in the feed dispersion. Antibacterial activity of NP formulations was determined by microdilution method. After minimum inhibitory concentration (MIC) determination, time-dependent activity for NP-2 was investigated by the time-kill method. MIC value for NP-2 was 4-fold lower than MIC value of CEF for Staphylococcus aureus and Escherichia coli. No growth was observed for both bacteria with NP-2 during 18 hours incubation in the time-kill method. As a result, prolonged antibiotic release and long-term antibacterial activity were obtained by NP-2, the optimum formulation of our study.

Remineralization Agents and Nanopharmaceutical Approaches That Have an Important Place in Dental Therapies and Preventive Dentistry: Traditional Review

“…Kişiselleştirilmiş ilaç tedavisi, nanopartikül (NP) bazlı ilaç taşıyıcı sistemleri, ilaç konjugatları, terapötik ilaç izleme, uyarıcıya duyarlı hedefe yönelik terapi gibi birçok strateji gibi yaklaşımlar, araştırmacılar tarafından kapsamlı bir şekilde incelenmiş ve incelenmeye devam etmektedir. 1,2 Çözelti, emülsiyon, süspansiyon, toz, tablet, kapsül, supozituvar gibi bilinen geleneksel/konvansiyonel ilaç taşıyıcı sistemlerin hazırlanmasında kullanılan yüksek doz ilaç etken maddesi ve buna bağlı olarak yüksek yan etki, düşük terapötik/farmakolojik etki, ilk geçiş etkisi gibi özellikleri geleneksel ilaç taşıyıcı sistemlerin dezavantajları olarak karşımıza çıkmakta ve bunların kullanımlarını sınırlamaktadır. Kullanılan bu geleneksel ilaç taşıyıcı sistemlerde emilen etkin maddenin plazma düzeyinde dalgalanma yapması ve plazmada bulunan ilaç konsantrasyonunda sürekli değişim gözlenip sabitlenememesinden dolayı farklı ve yeni ilaç taşıyıcı sistemlere ihtiyaç duyulmuştur.…”

Preparation, Characterization, Antioxidant Activities, and Determination of Anti-Alzheimer Effects of PLGA-Based DDSs Containing Ferulic Acid

“…However, a more efficient strategy to enhance therapy may be to increase the bioavailability, targeting, efficacy, and safety of medications presently used in clinics. Researchers frequently develop drug delivery systems using nanocarriers for this reason . Regarding the usage of multifunctional nanopharmaceuticals, there are numerous instances in the literature and clinical settings, including those involving liposomes, polymeric nanoparticles (NPs), solid lipid NPs, quantum dots, iron oxide NPs, gold NPs, dendrimers, micelles, and carbon nanotubes .…”

“…Researchers frequently develop drug delivery systems using nanocarriers for this reason. 6 Regarding the usage of multifunctional nanopharmaceuticals, there are numerous instances in the literature and clinical settings, including those involving liposomes, polymeric nanoparticles (NPs), solid lipid NPs, quantum dots, iron oxide NPs, gold NPs, dendrimers, micelles, and carbon nanotubes. 7 Today, NP-based medicines have a wide range of applications, and advances in nanotechnology offer new ways to approach treating medical conditions.…”

Evaluation of Cell Proliferation and Wound Healing Effects of Vitamin A Palmitate-Loaded PLGA/Chitosan-Coated PLGA Nanoparticles: Preparation, Characterization, Release, and Release Kinetics

“…The researchers have thoroughly investigated a number of strategies, including drug conjugates, therapeutic drug monitoring, targeted medication therapy, and nanoparticle (NP)-based drug delivery systems. 1 , 2 Besides, there are different approaches. Examples of these are conceptually innovative strategies to exploit ferroptosis against tumors, bidrug nanoplatforms, and drug carrier-free photodynamic nanodrugs to enable the regulation of dendritic cells.…”