Design of chitosan-alginate core-shell nanoparticules loaded with anacardic acid and cardol for drug delivery

Abstract

Anacardic Acid (AA) and Cardol (CD) are the main constituents of the cashew nut shell liquid, which presented several biological activities. In this study, a 2 3 factorial experimental design was employed in order to evaluate the influence of the reaction conditions in the nanoencapsulation of AA and CD using Chitosan (CH), Alginate (ALG) and Arabic Gum matrices. The nanoparticles (NPs) with higher stability and encapsulation efficiency were those with ALG as an outer coating and with lower content of surfactant. The NPs presented nanometric size with 90% of the distribution ranging from 70 to 250 nm. The in vitro kinetics revealed that CH-ALG/AA and CH-ALG/CD NPs followed zero-order kinetics model, showing a significantly slow release rate, with values of 33% and 63%, respectively, after 240h. Particularly, CH-ALG/CD NPs presented higher inhibitory capacity for all strains of dermatophytes due to their release rate, with promising results for antimicrobial control.

Antimicrobial and antioxidant activity of encapsulated tea polyphenols in chitosan/alginate-coated zein nanoparticles: a possible supplement against fish pathogens in aquaculture

“…It follows, under these conditions, that not all amino groups present in chitosan, which confer the polymer with a positive charge, are counteracted by the negative charge of carboxylic acids associated with alginate, leaving the potential to interact with the cell cytoplasmic membrane through their negative charges (Al-Gethami and Al-Qasmi 2021 ). However, it is not advisable to generalize these conclusions, since the results associated with each of the components can vary depending on the microorganism used in the assay (Asadpoor et al 2021 ; Paiva Filho et al 2020 ).…”

Profiling of Single Garlic Extract Microencapsulation: Characterization, Antioxidant Activity, and Release Kinetic

“…7.01 (Malvern Instruments Ltd.) with Dynamic Light Scattering (DLS) technique (Sorasitthiyanukarn et al 2018). MCA-SGE samples that have been diluted with deionized water are placed in a cuvette for analysis at 25 o C (Natrajan et al 2015;Filho et al 2019).…”

“…The MCA-SGE graph shows some additional absorptions that provide information on the functional groups of the encapsulated material. Chitosan gives rise to absorption at 1634.44 cm -1 which is the am- ide I functional group (Filho et al 2019). Another material that gives rise to absorption at 1732.85 cm -1 is an ester group that can be found in sodium alginate (Szabó et al 2020).…”

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“…Authors pointed out that in encapsulated form, inhibitory and fungicidal values were reduced due to dosage-controlled release. Therefore, it is important to highlight that characteristics obtained from nanoparticles not only gave stability and efficiency in encapsulation, but also allowed a prolonged antimicrobial effect 61 . Regarding parasites, use of nanocochleates (nanocarriers) with essential oil of Artemisia absinthium (EO-Aa-NC) to treat cutaneous leishmaniasis has yielded results that should be considered.…”