Design of cholesterol arabinogalactan anchored liposomes for asialoglycoprotein receptor mediated targeting to hepatocellular carcinoma: In silic o modeling, in vitro and in vivo evaluation

Pathak, Pankaj O.; Dhawan, Vivek; Magarkar, Aniket; Danne, Reinis; Govindarajan, Srinath; Ghosh, Sandipto; Steiniger, Frank; Chaudhari, Pradip; Gopal, Vijaya; Bunker, Alex; Róg, Tomasz; Fahr, Alfred; Nagarsenker, Mangal S.

doi:10.1016/j.ijpharm.2016.05.041

Cited by 30 publications

(14 citation statements)

References 46 publications

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“…It was observed to be rapidly eliminate from the bloodstream and pass to the liver following intravenous injection, making it a viable liver-targeting carrier. Dox liposome modified with cholesterol arabinogalactan exhibited an effect on hepatocellular carcinoma (HCC) [14]. Moreover, the enhancement of immune properties of arabinogalactan could enhance pharmacological activity [15].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics, biodistribution and receptor mediated endocytosis of a naturalAngelica sinensispolysaccharide

Zhou

Luo

Cui

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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The interest in developing new drug carriers for delivery to the liver using natural polysaccharides with a high galactose content has necessitated the study of the pharmacokinetics and tissue distribution of these polysaccharides. In this paper, a new method was established for the microanalysis of Angelica sinensis polysaccharide (ASP) in biosamples. Fluorescein-labelled ASP (FA) was rapidly eliminated from the bloodstream and distributed to the liver with high specificity following intravenous injection. The analysis of the hepatocellular localization demonstrated that FA was predominantly endocytosed by the parenchymal cells, an observation consistent with the results obtained from microscopy studies. Additionally, FA showed a high affinity for asialoglycoprotein receptor-rich cells, while minimal binding of FA to asialoglycoprotein receptor-poor cells was observed. Moreover, the absorption of FA was markedly inhibited by the co-administration of neogalactosylalbumin (NGA) both in vivo and in vitro. To allow for the visualization of the systemic circulation of ASP, Tc-DTPA-ASP was synthesized and in vivo imaging was performed with single photon emission computed tomography (SPECT). It also showed a high aggregation ofTc-DTPA-ASP in liver. These results suggest that the distribution of ASP to the liver occurs via asialoglycoprotein receptor (ASGPR) mediated endocytosis and ASP could potentially be applied as a new carrier for delivering drugs to the liver.

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetics, biodistribution and receptor mediated endocytosis of a naturalAngelica sinensispolysaccharide

Zhou

Luo

Cui

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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“…Mitoxantrone‐loaded liposomes were prepared using the ammonium sulphate gradient method . Briefly, PC, cholesterol and DSPE‐PEG 2000 in the molar ratio of 11 : 9 : 1 were dissolved in chloroform and dried to a thin lipid film at 40 °C by rotary vacuum evaporation (Rotary Evaporator R201D, Yukang, China).…”

Section: Methodsmentioning

confidence: 99%

Oestrone-targeted liposomes for mitoxantrone delivery via oestrogen receptor – synthesis, physicochemical characterization and in-vitro evaluation

Hao

Yang

Sun

et al. 2017

Journal of Pharmacy and Pharmacology

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“…Just such a polymer exists: Poly-methoxazoline (PMOZ); in a subsequent study we performed a simulation with the PEG corona replaced by a PMOZ corona and we saw increased exposure of the AETP moiety (Magarkar et al, 2017). We have also studied liposomes functionalized with stearylamine arginine ligands (Pathak et al, 2016). A comprehensive review of the theoretical and computational investigation of nanoparticle interactions with biomembranes has been written by Ding and Ma (2014b).…”

Section: Nanoparticlesmentioning

confidence: 99%

Mechanistic Understanding From Molecular Dynamics Simulation in Pharmaceutical Research 1: Drug Delivery

Bunker

Róg

2020

Front. Mol. Biosci.

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In this review, we outline the growing role that molecular dynamics simulation is able to play as a design tool in drug delivery. We cover both the pharmaceutical and computational backgrounds, in a pedagogical fashion, as this review is designed to be equally accessible to pharmaceutical researchers interested in what this new computational tool is capable of and experts in molecular modeling who wish to pursue pharmaceutical applications as a context for their research. The field has become too broad for us to concisely describe all work that has been carried out; many comprehensive reviews on subtopics of this area are cited. We discuss the insight molecular dynamics modeling has provided in dissolution and solubility, however, the majority of the discussion is focused on nanomedicine: the development of nanoscale drug delivery vehicles. Here we focus on three areas where molecular dynamics modeling has had a particularly strong impact: (1) behavior in the bloodstream and protective polymer corona, (2) Drug loading and controlled release, and (3) Nanoparticle interaction with both model and biological membranes. We conclude with some thoughts on the role that molecular dynamics simulation can grow to play in the development of new drug delivery systems.

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Design of cholesterol arabinogalactan anchored liposomes for asialoglycoprotein receptor mediated targeting to hepatocellular carcinoma: In silic o modeling, in vitro and in vivo evaluation

Cited by 30 publications

References 46 publications

Pharmacokinetics, biodistribution and receptor mediated endocytosis of a naturalAngelica sinensispolysaccharide

Pharmacokinetics, biodistribution and receptor mediated endocytosis of a naturalAngelica sinensispolysaccharide

Oestrone-targeted liposomes for mitoxantrone delivery via oestrogen receptor – synthesis, physicochemical characterization and in-vitro evaluation

Mechanistic Understanding From Molecular Dynamics Simulation in Pharmaceutical Research 1: Drug Delivery

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