Abstract-A quad band-notched compact ultra-wideband (UWB) patch antenna to operate on the industry, scientific, and medical (ISM) bands are presented in this study. A modified hexagonal patch vertex-fed with a coplanar waveguide (CPW) is fabricated on an FR-4 substrate with size of 43 × 28 × 1.6 mm 3 and fractional bandwidth of 133%. The compact antenna operates at a frequency of 2.45 GHz, which is often required for the efficient performance of ISM utilisation. The existing bands share the same bandwidth as that of UWB systems. Therefore, a notched band at 3 GHz for worldwide interoperability for microwave access (WiMAX), and a further resonance band at 2.45 GHz for ISM are generated by implementing a meander-line strip on the antenna. Furthermore, the design demonstrates a couple of F-shaped slots and an inverted diamond-shaped slot on the patch. Moreover, a pair of Jshaped slots is loaded on the ground plane. The downlink C-band, wireless local area network (WLAN), and downlink X-band are rejected by the proposed slots, respectively. The current distribution, gain, radiation efficiency, and quad notched parameters of the proposed antenna are studied by using CST software. The demonstrated prototype covers an ISM band at (2.2 GHz-2.6 GHz) with a return loss of −23.45 dB and omnidirectional radiation patterns. A good agreement is observed between measured and the simulated results. This paper has presented a solution for both interference and miniaturised issues.