Design of configuration-restricted triazolylated β-d-ribofuranosides: a unique family of crescent-shaped RNase A inhibitors

Abstract

A new series of carbohydrate-bistriazole hybrid molecules were designed and subsequently screened for their RNase A inhibitory potency by different biophysical techniques and docking studies.

“Copper catalyzed azide alkyne cycloaddition” based synthesis and applications of oligo-1, 2, 3-triazoles connected by suitable building blocks and “N-(CH)n-C” linked triazole oligomers

“…This final product was shown to be a moderate inhibitor of RNase A (Scheme 3.8). 51 Minigastrin (H-Leu-Glu-Glu-Glu-Glu-Glu-Ala11-Tyr12-Gly13-Trp14-Met15-Asp16-Phe17-NH2) is a potential drug for thyroid carcinoma. The radiolabeled shorter version of minigastrin, for example, leutetium ( 177 Lu) labeled tumor-targeting analog (DOTA-DGlu 10 -Ala 11 -Tyr 12 -Gly 13 -Trp 14 -Nle 15 -Asp 16 -Phe 17 -NH2,) is a useful therapeutic agent for targeting such tumors.…”

Comprehensive Analysis of Methyl-β-D-ribofuranoside: A Multifaceted Spectroscopic and Theoretical Approach

“…Methyl-β- D -ribofuranoside (Figure ), a representative of furanosides, plays a vital role in various natural compounds and biochemical processes. This molecule has garnered scientific interest due to its structural and dynamical properties. − While X-ray and neutron diffraction has provided valuable structural insights, − nuclear magnetic resonance spectroscopy has probed its conformations in solution. − Vibrational spectroscopy is an essential tool for probing the structure and dynamics of complex molecules, − providing insights into bonding interactions, functional groups, conformation, and molecular environment. For studying carbohydrates in particular, Raman spectroscopy and Raman optical activity measurements are state of the art techniques which exploit the chirality of the molecules to establish structural characteristics .…”

Characteristic 1H NMR spectra of β-d-ribofuranosides and ribonucleosides: factors driving furanose ring conformations

“…16 Simple b-D-ribofuranosides are oen used as intermediate products in the syntheses of more sophisticated ribose derivatives. [17][18][19] b-D-Ribofuranosides possessing phenolic aglycones were synthesized and found to exhibit the Src kinase inhibitory activity. 20 Generally, glycosidation of D-ribose is of interest to organic chemists.…”