Cyber-physical systems, where software and physical infrastructure are intertwined are promising technologies for re-imagining urban life. As CPS apply tightly coupled networks of sensors and actuators, supported by advanced data analytics, the field has great potential for addressing many aspects of city life and improving the quality of life of city inhabitants. Global urban development and itself increasing complication of the processes involved have produced considerable demand for fresh approaches to various local problems, extending from transport management to energy consumption, disease prevention, and preservation of natural resources. Moreover, CPS can be helpful in conservative consumption of resources: energy, water supply, and others in cities. Addressing these challenges via adaptive policies and frameworks, ethical imperatives, as well as special attention to the principles of smart design, will be vital for the successful translation of the potentials of CPS for improved efficiency, sustainability, and equity in urban settings.