Fluorescent Analogs of Biomolecular Building Blocks 2016
DOI: 10.1002/9781119179320.ch7
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Design of Environmentally Sensitive Fluorescent Nucleosides and their Applications

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Cited by 5 publications
(3 citation statements)
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“…The fluorophore sensitivity to the environmental polarity in biological membranes can be related to the dipole moment of the molecule in their excited state when compared to the ground state. The phenomenon of solvatochromism is the ability for a solvent to lower the fluorophore excited state that can shift its emission maximum . Hence, solvatochromic fluorescent lipid probes have been used to explore the polarity of membranes .…”
Section: Strategies For Building Fluorescent Glycerophospholipidsmentioning
confidence: 99%
“…The fluorophore sensitivity to the environmental polarity in biological membranes can be related to the dipole moment of the molecule in their excited state when compared to the ground state. The phenomenon of solvatochromism is the ability for a solvent to lower the fluorophore excited state that can shift its emission maximum . Hence, solvatochromic fluorescent lipid probes have been used to explore the polarity of membranes .…”
Section: Strategies For Building Fluorescent Glycerophospholipidsmentioning
confidence: 99%
“…7,8 The synthetic design is even more challenging when optimal photophysical properties and/ or intramolecular charge transfer characteristics towards microenvironment sensitivity are needed for live-cell imaging. [9][10][11] Chemical modifications to generate FNAs normally involve decorating commercial pyrimidines and purines with bulky and highly conjugated groups at C-2 or C-8, respectively, through cross-coupling condensation reactions. 12 The main constraints of FNAs for efficient and environmentally safe syntheses include the use of costly precursors and hazardous metal catalysts.…”
Section: Introductionmentioning
confidence: 99%
“…As a part of our continuous research efforts in the design of solvofluorochromic molecules/biomolecular building blocks, , we thought that it would be worthwhile to design dual-emissive modified nucleosides. Based on our experience, literature reports, and wider applicability, we considered design of C-5-labeled uridines as model nucleoside probes useable for DNA analysis in the future. ,, However, there is no report wherein C5-position of 2′-deoxyuridine is linked by an electron-donor unit as a postsynthetically modifiable functional group which effectively can generate a modulated fluorescence property of a fluorophore if attached at the terminus or the terminal alkyne can be reacted with a fluorophoric azide functionality. Previously, we have shown the “installation/modulation of fluorescence response” of various small fluorescent molecules and an interesting dual-emission behavior from pyrene when attached to the N,N -dimethylanilino triazole donor unit .…”
Section: Introductionmentioning
confidence: 99%