Semiconductor manufacturing is a complex and lengthy process. Even with their expertise and experience, engineers often cannot quickly identify anomalies in an extensive database. Most research into equipment combinations has focused on the manufacturing process’s efficiency, quality, and cost issues. There has been little consideration of the relationship between semiconductor station and equipment combinations and throughput. In this study, a machine learning approach that allows for the integration of control charts, clustering, and association rules were developed. This approach was used to identify equipment combinations that may harm production processes by analyzing the effect on Vt parameters of the equipment combinations used in wafer acceptance testing (WAT). The results showed that when the support is between 70% and 80% and the confidence level is 85%, it is possible to quickly select the specific combinations of 13 production stations that significantly impact the Vt values of all 39 production stations. Stations 046000 (EH308), 049200 (DW005), 049050 (DI303), and 060000 (DC393) were found to have the most abnormal equipment combinations. The results of this research will aid the detection of equipment errors during semiconductor manufacturing and assist the optimization of production scheduling.