Design of experiments applied to the study of the reaction between phenylphosphonic dichloride with bisphenol by inverse phase transfer catalysis method

Abstract

The reaction of phenylphosphonic dichloride with bisphenol A (BA) by inverse phase transfer catalysis method was investigated. The design of experiments method was applied to establish the correlation between the simultaneous influence of the parameters (alkaline medium, reaction temperature, reagents molar ratio, and stirring speed) on yield and inherent viscosity, as well as for identifying the best reaction conditions. This method allows the simultaneous variation of control factors, thus decreasing the number of experiments in the polyphosphate synthesis. The process control factors used in this study were reagents' molar ratio, base concentration, and reaction temperature. The experimental results using 20 and 14 process runs, lead to an optimal synthesis procedure. The optimal values for yield and viscosity were obtained at molar ratio = 1, base concentration = 1.1 M, and reaction temperature = 2128C and have been experimentally verified with a series of four runs.

Screening of mixing parameters based on their significance on the extent of silanization and energy consumption of silica‐filled S‐SBR elastomer compounds for fuel‐saving tyre application

“…Design of experiments (DOE) is widely used in research area to predict the properties, study the reaction, to optimize the process or reaction, and etc. [19][20][21] The design of experiments deals with evaluating factors responsible for controlling a parameter or a group of parameters by conducting controlled tests and thereby estimating the optimum processing condition. DOE helps to investigate either all possible combinations or a part of possible combinations.…”