Design of experiments (DoE) to model phenolic compounds recovery from grape pomace using ultrasounds

Ćućuz, Veljko; Cvejić, Jelena; Torović, Ljilja; Gojkovic-Bukarica, Ljiljana; Acevska, Jelena; Dimitrovska, Aneta; Aldawoud, Turki M.S.; Galanakis, Charis M.

doi:10.1007/s13197-021-05317-9

Cited by 9 publications

(3 citation statements)

References 32 publications

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“…There are a limited number of studies focused on the design of phytocompounds extraction, mainly on non-edible residues, such as sea buckthorn leaves [11][12][13], winery by-products [14,15], apples [16] and potato peels [17][18][19]. The polyphenols extraction from bilberry pomace was studied through central composite design and response surface methodology (RSM) [20], while bilberry fruit extraction using the Box-Behnken design [7] or RSM [21] was also reported.…”

Section: Introductionmentioning

confidence: 99%

Optimisation of Polyphenols Extraction from Wild Bilberry Leaves—Antimicrobial Properties and Stability Studies

et al. 2023

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Polyphenolic extracts from natural sources have received great interest due to their beneficial properties for human health. A method to reduce their variability is to use the design of experiments which allows a limited number of experiments to be performed while exploring the experimental space. Firstly, a 23-full factorial model was used to investigate the polyphenols extraction from wild bilberry leaves. Spectrophotometric data (the content of polyphenols, flavonoids, chlorophyll and radical scavenger activity) and extraction yield were used as responses, and six statistical models were determined depending on the two numerical factors (temperature and alcohol % of ethanol–water mixture) being significant (p < 0.05) in all cases. Numerical optimisation performed by Design Expert 13 software correlates well with the chemical profile determined by high-performance liquid chromatography and the amount of the polyphenol. Afterwards, under the optimised conditions, an extract was prepared in three extraction steps for which composition, chemical stability and antimicrobial properties were evaluated. The antimicrobial potential of the extract was compared with that of the standard compounds (rutin and chlorogenic acid), and the results supported a synergistic effect of the extract components.

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Section: Introductionmentioning

confidence: 99%

Optimisation of Polyphenols Extraction from Wild Bilberry Leaves—Antimicrobial Properties and Stability Studies

et al. 2023

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“…The extraction conditions determine the quality and the yield of the individual constituents; therefore, the choice of the extraction method becomes one of the most important stages in the development of modern phytopharmaceuticals [ 19 ]. One of the approaches worth implementing for the preparation of herbal extracts is the design of experiment approach, which assesses the influence of input factors (e.g., temperature, the composition of the extraction mixture and extraction method) on the properties of the extract (e.g., content of active compounds and biological activity) [ 19 , 20 ]. In this work, a full factorial design model was created to assess the effectiveness of the extraction process ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Is It Possible to Improve the Bioavailability of Resveratrol and Polydatin Derived from Polygoni cuspidati Radix as a Result of Preparing Electrospun Nanofibers Based on Polyvinylpyrrolidone/Cyclodextrin?

Paczkowska-Walendowska

Miklaszewski

Cielecka‐Piontek

2022

Nutrients

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The low bioavailability of resveratrol and polydatin obtained from Polygoni cuspidati extract limits the application of their pro-health properties. While nanofibers have attracted increasing attention in nutrition delivery due to their special properties, including an increase in the dissolution and permeability, which affects the bioavailability. Therefore, it is justified to obtain nanofibers from Polygoni cuspidati extract, which showed antioxidant and anti-inflammatory properties as a result of a presence of stilbene analogs in the Polygoni cuspidati extract (especially resveratrol and polydatin). In the first stage of the work, using the Design of Experiment (DoE) approach, the Polygoni cuspidati extract (70% of methanol, temperature 70 °C and 4 cycles) was obtained, which showed the best antioxidant and anti-inflammatory properties. Using the Polygoni cuspidati extract as a substrate, nanofibers were obtained by electrospinning. The identification of nanofibers was confirmed on the basis of the analysis of changes in XRPD diffractograms, SEM picture and FTIR-ATR spectra. Obtaining nanofibers from the Polygoni cuspidati extract significantly improved the solubility of resveratrol and polydatin (approx. 6-fold comparing to pure substance). As a consequence, the penetration coefficients of both tested resveratrol and polydatin also increased. The proposed strategy for the preparation of nanofibers from the Polygoni cuspidati extract is an innovative approach to better use the synergy of biological action of active compounds present in extracts. It is especially during the development of nutraceuticals based on the use of selected stilbenes.

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“…This can be attributed to the influence of solution polarity due to the presence of water in the extraction solvent, which enhanced the release of water-soluble phytochemicals. These parameters were chosen for further optimization using a 2 3 -full factorial central composite face design [108]. Similarly, in the extraction of polyphenols from rice Caro pods (L11 PBD), particle size was found to affect the process significantly.…”

Section: Plackett-burman Designmentioning

confidence: 99%

Design of Experiments for Optimizing Ultrasound-Assisted Extraction of Bioactive Compounds from Plant-Based Sources

Anaya-Esparza,

Aurora-Vigo,

Villagrán

et al. 2023

Molecules

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Plant-based materials are an important source of bioactive compounds (BC) with interesting industrial applications. Therefore, adequate experimental strategies for maximizing their recovery yield are required. Among all procedures for extracting BC (maceration, Soxhlet, hydro-distillation, pulsed-electric field, enzyme, microwave, high hydrostatic pressure, and supercritical fluids), the ultrasound-assisted extraction (UAE) highlighted as an advanced, cost-efficient, eco-friendly, and sustainable alternative for recovering BC (polyphenols, flavonoids, anthocyanins, and carotenoids) from plant sources with higher yields. However, the UAE efficiency is influenced by several factors, including operational variables and extraction process (frequency, amplitude, ultrasonic power, pulse cycle, type of solvent, extraction time, solvent-to-solid ratio, pH, particle size, and temperature) that exert an impact on the molecular structures of targeted molecules, leading to variations in their biological properties. In this context, a diverse design of experiments (DOEs), including full or fractional factorial, Plackett–Burman, Box-Behnken, Central composite, Taguchi, Mixture, D-optimal, and Doehlert have been investigated alone and in combination to optimize the UAE of BC from plant-based materials, using the response surface methodology and mathematical models in a simple or multi-factorial/multi-response approach. The present review summarizes the advantages and limitations of the most common DOEs investigated to optimize the UAE of bioactive compounds from plant-based materials.

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Design of experiments (DoE) to model phenolic compounds recovery from grape pomace using ultrasounds

Cited by 9 publications

References 32 publications

Optimisation of Polyphenols Extraction from Wild Bilberry Leaves—Antimicrobial Properties and Stability Studies

Optimisation of Polyphenols Extraction from Wild Bilberry Leaves—Antimicrobial Properties and Stability Studies

Is It Possible to Improve the Bioavailability of Resveratrol and Polydatin Derived from Polygoni cuspidati Radix as a Result of Preparing Electrospun Nanofibers Based on Polyvinylpyrrolidone/Cyclodextrin?

Design of Experiments for Optimizing Ultrasound-Assisted Extraction of Bioactive Compounds from Plant-Based Sources

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