Design of Experiments-Driven Optimization of Spray Drying for Amorphous Clotrimazole Nanosuspension

Gajera, Bhavin; Shah, Harsh; Parekh, Bhavin; Rathod, Vishal; Tilala, Mitul; Dave, Rutesh H.

doi:10.1208/s12249-024-02871-1

AAPS PharmSciTech

2024

DOI: 10.1208/s12249-024-02871-1

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Design of Experiments-Driven Optimization of Spray Drying for Amorphous Clotrimazole Nanosuspension

Bhavin Gajera,

Harsh Shah,

Bhavin Parekh

et al.

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Cited by 3 publications

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Kubernetes Autoscaling Mechanism for Integration into Cloud Services to Achieve Cost Efficiency Organizations have turned towards containerized applications and microservices architecture. Optimizing and using resources appropriately as per the expected operational cost becomes the need of the hour. There are several autoscaling mechanisms within Kubernetes, that include Horizontal Pod Autoscaler, Vertical Pod Autoscaler, and Cluster Autoscaler, working towards cost optimization. We study predictive scaling algorithms, multi-dimensional autoscaling strategies, and machine learning-based approaches for resource allocation. Among the new challenges of implementing the solution are the methodologies followed in evaluating the research, which also involves complex advanced optimization techniques: from integrating serverless, towards multicloud autoscaling. Our findings will give an understanding of the status quo of Kubernetes autoscaling towards cost efficiency and recommendations for future research and industrial implementation.

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Int. J. Sci. Res. Comput. Sci. Eng. Inf. Technol

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Phycotoxins are toxic substances which are generated by varieties of algae; marine phycotoxins are particularly dangerous to the neurological welfare of children. The types of marine phycotoxins, their neurotoxic action, and the management of exposure in children are all examined in this paper. It is just in this case that the patient undergoes early evaluation of signs of a chronic illness, and the prevention of the worsening of the condition and its impact on the neurological system. In total, the present research aims at analyzing the short and the long-term effects of the mentioned toxins with the purpose of providing a broad look at the risks they present to neurodevelopment of children.

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The present work aims at analyzing the effects of the climate change on neurodevelopmental disorders in children. The document dwells on the importance of neuro-toxic stressors in pollution and climatic changes affect neurological risks in children. Specifically, this research will examine the following questions: the causal mechanisms by which climate change impacts neurodevelopment; the related health consequences on children; and protective strategies for these populations. Through these linkages, the paper underscores the need for policy change and community mobilisation to protect children as they are affected by climate change.

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Design of Experiments-Driven Optimization of Spray Drying for Amorphous Clotrimazole Nanosuspension

Cited by 3 publications

References 42 publications

Integrating Kubernetes Autoscaling for Cost Efficiency in Cloud Services

Integrating Kubernetes Autoscaling for Cost Efficiency in Cloud Services

Effect of Marine Phycotoxins on Pediatric Neurological Health

Impact of Climate Change on Neurodevelopmental Disorders in Pediatrics

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