Design of floating formulations and antiulcer activity of Desmostachya bipinnata
Sanjay Kumar Putta,
Koteshwara KB,
Usha Y. Nayak
et al.
Abstract:The study aims to design and optimize the floating formulations of the aqueous extract of Desmostachya bipinnata (ADB) to treat peptic ulcers. The trial concentrations of HPMC E50, HPMC K4M, and Carbopol 940 were used as factors, and floating lag time, total floating time, and % drug release at 12 h were used as responses. The formulation underwent evaluation for different parameters: aspirin-induced ulcers in rats assessed the antiulcer activity, and X-ray studies in rabbits evaluated the gastroretentive natu… Show more
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