This paper presents a high-selectivity, low-insertion-loss open-loop resonator (OLR)-based microstrip diplexer designed for wireless communication systems. We employed a microstrip transmission line with two serial capacitive gaps, incorporating rectangular half-wavelength open-loop resonators, to create a bandpass filter (BPF) with remarkable selectivity. The intended BPFs are interconnected by a T-junction combiner, which is matched to both filters and the antenna port, thereby creating the modelled diplexer. The system is implemented on a Rogers TMM4 substrate featuring a loss tangent of 0.002, a dielectric constant of 4.7, and a thickness of 1.52 mm. The suggested diplexer has dimensions of (90×70) mm². It achieves a modest frequency spacing ratio of R=0.1646 in both transmit and receive modes, with resonance frequencies of ft = 2.191 GHz and fr = 2.584 GHz, respectively. The simulated structure demonstrates favorable insertion losses of approximately 1.2 dB and 1.79 dB for the two channels at fractional bandwidths of 1.24% (2.191 GHz) and 0.636% (2.584 GHz). The simulated isolation values at 2.191 GHz and 2.584 GHz are 53.3 dB and 66.5 dB, respectively. Notably, the simulated and measured results exhibit a high degree of consistency. However, minor variations between the simulated and actual results have been noted, primarily attributable to the inherent fabrication tolerances.