First of all, I would like to express my deepest and sincere gratitude to my supervisor, Dr. Siek Liter for his priceless guidance and encouragement throughout my studies. Dr. Siek is inspirational, knowledgeable, understanding, helpful, cheerful, etc. He has all the traits of a great professor. I truly appreciate his patience and continuous guidance which help to cultivate my analytical thinking skills as well as problem solving skills. I am deeply thankful for his encouragement especially during the most difficult time of my PhD journey. Next, I would like to thank EDB and my sponsored company, Maxim Integrated for funding my studies and providing me a short training. I would also like to thank NTU-A*STAR Silicon Technologies Centre of Excellence, School of Electrical and Electronic (EEE) for supporting the chip fabrication and also VIRTUS for providing me a conducive research environment. Besides, I would also like to thank my seniors, Sun ZhuoChao and Roy Chew Kin Wai for sharing their knowledge and experiences with me, which helps to widen my perspectives on the research areas. My gratitude is also extended to my fellow teammates and friends