To conduct centralized management combined with Information system application management in radiology instruments and reusable medical devices, and explore the promotion value of cleaning quality and work efficiency. The recycling time, cleaning quality, packaging quality and distribution errors of the devices with which centralized management combined with Information system application management (June 2019) was implemented half a year before and after in the radiology department of our hospital were collected and compared. With implementation of centralized management combined with Information system application management, the average recycling time (25.33 ± 5.64) of devices was remarkably shorter than that before implementation (42.37 ± 6.77) (P < 0.05). The yield of cleaning (94.57%) and packaging (98.91%) in the observation group were significantly higher than those in the control group (86.05%) and (87.21%) (P < 0.05). The probability of distribution error (8.70%) and recycling error (5.43%) of devices in the observation group were significantly lower than those in the control group (19.77% and 18.60%) (P < 0.05). Centralized management combined with Information system application management effectively improves the cleaning quality and work efficiency of radiology instruments and reusable instruments, indicating long-term application value.