2022
DOI: 10.1021/acsabm.1c01269
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Design of Injectable Poly(γ-glutamic acid)/Chondroitin Sulfate Hydrogels with Mineralization Ability

Abstract: Biocompatible hydrogels are considered promising agents for application in bone tissue engineering. However, the design of reliable hydrogels with satisfactory injectability, mechanical strength, and a rapid biomineralization rate for bone regeneration remains challenging. Herein, injectable hydrogels are fabricated using hydrazide-modified poly(γglutamic acid) and oxidized chondroitin sulfate by combining acylhydrazone bonds and ionic bonding of carboxylic acid groups or sulfate groups with calcium ions (Ca 2… Show more

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Cited by 7 publications
(2 citation statements)
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“…The compression testing was carried out on the intact hydrogel at 0.5 mm/s and self-healed hydrogel (wedge is aligned to the junction of healing). The maximum force recorded was noted, and healing efficiency (HE) was calculated using the equation reported by Wei et al HE = F normali F normals × 10 where F i and F s denote the fracture forces of intact and self-healed hydrogels, respectively.…”
Section: Materials and Methodsmentioning
confidence: 99%
“…The compression testing was carried out on the intact hydrogel at 0.5 mm/s and self-healed hydrogel (wedge is aligned to the junction of healing). The maximum force recorded was noted, and healing efficiency (HE) was calculated using the equation reported by Wei et al HE = F normali F normals × 10 where F i and F s denote the fracture forces of intact and self-healed hydrogels, respectively.…”
Section: Materials and Methodsmentioning
confidence: 99%
“…The ultimate degradation product of PGA is glutamate, a component of collagen. Due to its excellent biocompatibility, biodegradability, and non-toxicity, PGA is used to prepare hydrogels with various functions for tissue engineering matrix, especially cartilage ( Wei et al, 2022 ).…”
Section: Materials Of Injectable Hydrogelsmentioning
confidence: 99%