Design of iron chelators with therapeutic application

Liu, Zu D.; Hider, Robert C.

doi:10.1016/s0010-8545(02)00050-4

Cited by 268 publications

(260 citation statements)

References 100 publications

Supporting

Mentioning

255

Contrasting

Unclassified

Order By: Relevance

“…[65][66][67][68][69][70][71][72][73] Most uses of chelating materials are based on the stable complexation of metal ions by multi-dentate or cyclic ligands which are entropically favored by the ionic chelate over the main solvent molecules, whether organic solvents or water. The concept of scavenging Mn cations and HF from the electrolyte solution of an LMO-graphite cell was first proposed by Tarascon and coworkers in 1999 13 .…”

Section: A6316mentioning

confidence: 99%

Review—Multifunctional Materials for Enhanced Li-Ion Batteries Durability: A Brief Review of Practical Options

Banerjee

Shilina

Ziv

et al. 2017

J. Electrochem. Soc.

View full text Add to dashboard Cite

Transition metal (TM) ions dissolution from positive electrodes, migration to and deposition on negative electrodes, followed by Mn-catalyzed reactions of solvents and anions, with loss of Li + ions, is a major degradation (DMDCR) mechanism in Li-ion batteries (LIBs) with spinel positive electrode materials. While the details of the DMDCR mechanism are still under debate, it is clear that HF and other acid species' attack is the main cause in solutions with LiPF 6 electrolyte. We first review the work on various mitigation measures for the DMDCR mechanism, now spanning more than two decades. We then discuss recent progress on our understanding of Mn species in electrolyte solutions and the extension of a mitigation measure first proposed by Tarascon and coworkers in 1999, namely chelation of TM cations, to Mn cation trapping, HF scavenging, and alkali metal ions dispensing multi-functional materials. We focus on practicable, drop-in technical solutions, based on placing such materials in the inter-electrode space, with significant benefits for LIBs performance: increased capacity retention during operation at room and above-ambient temperatures as well as robust (both maximally ionically conducting and electronically insulating) solid-electrolyte interfaces, having reduced charge transfer and film resistances at both negative and positive electrodes. We illustrate the multifunctional materials approach with both new and previously published data. We also discuss and offer our evaluation regarding the merits and drawbacks of the various mitigation measures, with an eye for practically relevant technical solutions capable to meet both the performance requirements and cost constraints for commercial LIBs, and end with recommendations for future work. Li-ion batteries (LIBs) dominate the global market for energystorage devices nowadays and are used in a variety of applications, ranging from portable consumer electronics, to electrical grid storage, to load-levelling and electrified vehicles.1 Electrified vehicles are the most demanding among all LIBs applications in terms of both duty cycle and durability, since the batteries are subjected to a wide range of temperatures and charging/discharging rates, while customers expect a 10 years lifetime. Incessant research on various positive and negative active materials resulted in several promising electrode materials with various crystal structures and chemistries being developed over the past decades, such as layered (LiCoO 2 , LiNi 1-x-y Co x Al y O 2 , Ni 1-x-y Co x Mn y O 2 ), spinel (LiMn 2 O 4 , a.k.a. LMO; LNi 0.5 Mn 1.5 O 2 , a.k.a. LNMO), and olivine (LiFePO 4, LiVPO 4 ) for positive, as well as graphite, silicon, silicon-oxide, and lithium titanate for negative electrodes.2 New developments in electrode materials notwithstanding, LIBs for automotive transportation still need considerable improvements in terms of both performance and durability. Among transition metal (TM) oxide cathodes, LiMn 2 O 4 spinel would be most suited for automotive power cells due to i...

show abstract

Section: A6316mentioning

confidence: 99%

Review—Multifunctional Materials for Enhanced Li-Ion Batteries Durability: A Brief Review of Practical Options

Banerjee

Shilina

Ziv

et al. 2017

J. Electrochem. Soc.

View full text Add to dashboard Cite

show abstract

“…Many literature articles gave evidence to the developing significance of the discipline [1][2][3][4][5][6][7][8][9][10][11]. Several chelating agents used clinically may create in most pharmacopoeia [12], while other new one still being sought [13]. Due to Cu(II) free ion toxicity, many medical problems can be improved, such as using of chelating agents in treatment of Wilson's disease [14].…”

Section: Introductionmentioning

confidence: 99%

Complex Formation Reactions of Palladium(II) and Amlodipine Drug with Biologically Active Ligands

Al‐Qahtani¹,

Ammar²,

Al-Bedair³

et al. 2017

Asian J. Chem.

View full text Add to dashboard Cite

The stability constants of various complexes of [Pd(drug)(H2O)2] 2+ (drug = amlodipine) with peptides, (L) viz. glycylglycine, leucylalanine, glycylvaline, glycinamide and glutamine have been studied using potentiometric measurements. The complexes formation procedure has been predictable according to the pH range studied. A different complexes constants were determined under 0.1 mol/dm 3 NaNO3 and 25°C conditions such as stability and stoichiometries constants.

show abstract

“…28,30 Pyridinones have been proposed as oral therapeutic chelators for Fe III and Al III removal, 31,32 and the compound 1,2-dimethyl-3-hydroxy-4-pyridinone (Hdhp -Scheme 1), commercially known as Deferiprone®, is used in the treatment of β-thalassaemia. [31][32][33] The complexation of V IV O 2+ and V V O 2 + with dhp was studied in aqueous solution [34][35][36][37][38] and exhibited quite interesting insulin like properties. 12,13,39,40 Aiming at developing ligands with similar structural and binding ability characteristics of pyridinone and pyrone heterocycles, with improved aqueous solubility, we developed a distinct heterocyclic ligand system of the pyrimidinone type: 2-methyl-3H-5-hydroxy-6-carboxy-4-pyrimidinone ethyl ester, or mhcpe -Scheme 1 -containing two N atoms in the ring.…”

Section: Introductionmentioning

confidence: 99%

A novel VIVO–pyrimidinone complex: synthesis, solution speciation and human serum protein binding

Gonçalves¹,

Tomaz

Correia³

et al. 2013

Dalton Trans.

View full text Add to dashboard Cite

The pyrimidinones mhcpe, 2-methyl-3H-5-hydroxy-6-carboxy-4-pyrimidinone ethyl ester (mhcpe, 1), 2,3-dimethyl-5-benzyloxy-6-carboxy-4-pyrimidinone ethyl ester (dbcpe, 2) and N-methyl-2,3-dimethyl-5-hydroxy-6-carboxyamido-4-pyrimidinone (N-MeHOPY, 3), are synthesized and their structures determined by single crystal X-ray diffraction. The acid-base properties of 1 are studied by potentiometric and spectrophotometric methods, the pK a values being 1.14 and 6.35. DFT calculations were carried out to determine the most stable structure for each of the H 2 L + , HL and L − forms (HL = mhcpe) and assign the groups involved in the protonation-deprotonation processes. The mhcpe − ligand forms stable complexes with V IV O 2+ in the pH range 2 to 10, and potentiometry, EPR and UV-Vis techniques are used to identify and characterize the V IV O-mhcpe species formed. The results are consistent with the formation of V IV O,

show abstract

Design of iron chelators with therapeutic application

Cited by 268 publications

References 100 publications

Review—Multifunctional Materials for Enhanced Li-Ion Batteries Durability: A Brief Review of Practical Options

Review—Multifunctional Materials for Enhanced Li-Ion Batteries Durability: A Brief Review of Practical Options

Complex Formation Reactions of Palladium(II) and Amlodipine Drug with Biologically Active Ligands

A novel VIVO–pyrimidinone complex: synthesis, solution speciation and human serum protein binding

Contact Info

Product

Resources

About