Design of Lamivudine Loaded Nanoparticles for Oral Application by Nano Spray Drying Method: A New Approach to use an Antiretroviral Drug for Lung Cancer Treatment

Öztürk, A. Alper; Namlı, İrem; Güleç, Kadri; Görgülü, Şennur

doi:10.2174/1386207323666200325155020

Cited by 17 publications

(8 citation statements)

References 54 publications

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“…Considering previous studies, 14,16 it is known that the particle sizes of nanoparticles increase as a result of drug active ingredient/essential oil loading. The average PDI of the empty nanoparticle is 0.186, whereas the average PDI of Elemi EO-loaded PLGA nanoparticles is 0.259, respectively (Table 6).…”

Section: Discussionmentioning

confidence: 95%

Elemi essential oil nanocapsulated drug ameliorates lung cancer via oxidative stress, apoptosis and inflammation pathway

Kurban,

Tuncel,

Görgülü

et al. 2023

J Cellular Molecular Medi

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Lung cancer is one of the most common causes of death in the world. Considering the severe side effects, toxicity and high costs of chemotherapeutics used in cancer treatment, there is a need for more economical and natural treatment methods such as essential oils. The purpose of this study is to determine the efficacy of Canarium commune (Elemi) essential oil (EO) and nanoparticles. Elemi EO is analysed by GC‐FID/MS. The antiproliferative effect of Elemi EO and prepared nanoparticles on human lung adenocarcinoma (A549) and their effect on normal fibroblast cells (CCD‐19Lu) were determined by the MTT test. The levels of TAS, TOS, CYCS, CASP3, TNF‐α and IL‐6 parameters of the experimental groups were determined using specific ELISA. BAX and Bcl‐2 genes were studied with qRT‐PCR to investigate the different ways that cancer cells undergo apoptosis. Limonene (53.7%), a‐phellandrene (14.5%) and elemol (10.1%) were the major components of Elemi EO. 24‐Hour IC50 values in the cells were measured for Elemi EO; A549: 1199 μg/mL, CCD‐19Lu: 37.181 μg/mL. TAS and TOS values were found to be higher in cancer cells than in normal cells, and it was found that cancerous cells were dragged into stress and that cancer cells were directed to apoptosis. BAX genes stimulation supported the results. It was determined that Elemi EO and nanoparticles showed anticancer activity without damaging normal cells. Based on these promising results, potential drug candidate Elemi EO loaded nanoparticles may be cell‐specific targeted, oral use possible, new generation nanoparticular drugs.

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Section: Discussionmentioning

confidence: 95%

Elemi essential oil nanocapsulated drug ameliorates lung cancer via oxidative stress, apoptosis and inflammation pathway

Kurban,

Tuncel,

Görgülü

et al. 2023

J Cellular Molecular Medi

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“…Drug delivery systems and polymers used in drug delivery systems are a very important issue today and studies are continuing [81,[83][84][85][86][87]. Different drug delivery systems prepared with polymers are more advantageous and more promising than traditional drug delivery systems [81,[85][86][87][88][89][90][91][92][93]. Table 2 shows pharmaceutical R&D studies with PLGA in Turkey.…”

Section: Discussionmentioning

confidence: 99%

Latest research about active pharmaceutical ingredient loaded Poly Lactic Acid-co-Glycolic Acid (PLGA) based drug delivery system in Türkiye

et al. 2023

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Some of the most well-engineered and produced biomaterials are polyesters based on polyglycolic acid (PGA), polylactic acid (PLA), and their copolymers, polylactic acid co-glycolic acid (PLGA). In controlled release systems, PLGA is the most extensively used and popular polymer. Because of its biodegradability, biocompatibility, and favorable release kinetics, but also because of the reliability of protein delivery issues, this synthetic polymer has been found to be very successful. PLGA is approved in various human drug delivery systems by EMA and FDA. In this review, first, PLGA and historical development, usage, physico-chemical structure, drug release properties, degredation specifications, solubility, crystallinity, thermal stability, release properties, types of PLGA will be mentioned. In the last stage of the review, studies conducted in Türkiye are included. In conclusion, we believe that this review is a resource for researchers doing research with PLGA.

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“…Yellow MTT is reduced to purple formazan in the mitochondria of viable cells. This reduction takes place only when mitochondrial reductase enzymes are active, and therefore, the conversion can be directly related to the number of viable cells [39].…”

Section: Methodsmentioning

confidence: 99%

Synthesis and biological evaluation of novel 1,3,4‐oxadiazole derivatives as anticancer agents and potential EGFR inhibitors

Osmaniye

Görgülü

Sağlık

et al. 2021

Journal of Heterocyclic Chem

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EGFR (epidermal growth factor receptor) tyrosine kinases are frequently used in recent years, especially in small cell lung cancer. As with all other anticancer drugs, problems such as high side‐effect profiles and resistance to anticancer drugs call for new antiproliferative compounds. In the light of the above information, novel quinoxalin‐oxadiazole derivatives were synthesized as EGFR inhibitors in this study. Synthesis of compounds (3a–3j) was performed according to the literature methods. Their structures were elucidated by 1H‐NMR, 13C‐NMR, and HRMS spectroscopic methods. Structure elucidation was performed for compound 3e using 2D NMR technique. MTT test was performed to assess the cell proliferation effects of the different compounds on lung and mammary cell lines (A549, MCF7). In addition, obtained compounds (3a–3j) were screened against healthy CCD19‐Lu cell line (human lung fibroblast normal cells) to determine selectivity of the cytotoxic activities. Among the tested compounds, 3e and 3j showed significant cytotoxic activity against A549 cancer cell. Moreover, compound 3g and 3h displayed good activity. And the compounds 3e and 3j performed significant EGFR inhibition. Interaction modes of the compounds 3e, 3j were investigated against EGFR tyrosine kinase by means of docking studies. As a result of the studies, the importance of the quinoxaline ring and the NO2 substituent has been understood. In future studies, it is planned to make modifications by keeping these two structures constant. The activity can be contributed by using other heterocyclic rings instead of the oxadizaole ring.

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Design of Lamivudine Loaded Nanoparticles for Oral Application by Nano Spray Drying Method: A New Approach to use an Antiretroviral Drug for Lung Cancer Treatment

Cited by 17 publications

References 54 publications

Elemi essential oil nanocapsulated drug ameliorates lung cancer via oxidative stress, apoptosis and inflammation pathway

Elemi essential oil nanocapsulated drug ameliorates lung cancer via oxidative stress, apoptosis and inflammation pathway

Latest research about active pharmaceutical ingredient loaded Poly Lactic Acid-co-Glycolic Acid (PLGA) based drug delivery system in Türkiye

Synthesis and biological evaluation of novel 1,3,4‐oxadiazole derivatives as anticancer agents and potential EGFR inhibitors

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