Full-Color LED display-Screen is widely used as a new information display device in all aspects of life, the large Full-Color LED Display-Screen color is composed of enhanced MCU or ARM, but the real-time and flexibility of the control system do not satisfy the require of people ,With the continuous improvement of people's living standard. FPGA is favored by the embedded development generally,so a new Full-Color LED Display-Screen was designed based on FPGA and ARM, the system choose the Cortex-M3 ARM as kernel board controller, using the FPGA to scan and control display data, using WI-FI wireless network to communicate though the computer software. The test shows that the system is reasonable, realizable, operated easily, flexible, adaptable environment, low price. This system can support picture to display on 256 gray-scale full-color, and can be communicate with WI-FI on high speed and it will be used widely in the practical system.