Design of liposomes as drug delivery system for therapeutic applications

Guimarães, Diana Isabel Pereira; Cavaco-Paulo, Artur; Nogueira, E.

doi:10.1016/j.ijpharm.2021.120571

Cited by 651 publications

(353 citation statements)

References 143 publications

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“…In particular, extract powder was dispersed (up to 8 mg/ml) in tert-butanol, DMF, isopropanol, ethanol, and methanol. Nanoprecipitation by solvent injection technique [ 35 , 36 ] was performed to produce nanovesicles. In particular, 1 ml of solutions of myelin in DMF or tert-butanol (0.1 mg/ml) was added with a microsyringe over a 20-fold excess of ultrapure water under Ultraturrax® agitation (8000 rpm for 15 min).…”

Section: Methodsmentioning

confidence: 99%

Nano-structured myelin: new nanovesicles for targeted delivery to white matter and microglia, from brain-to-brain

Picone

Palumbo

Federico

et al. 2021

Materials Today Bio

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Neurodegenerative diseases affect millions of people worldwide and the presence of various physiological barriers limits the accessibility to the brain and reduces the efficacy of various therapies. Moreover, new carriers having targeting properties to specific brain regions and cells are needed in order to improve therapies for the brain disorder treatment. In this study, for the first time, Myelin nanoVesicles (hereafter defined MyVes) from brain-extracted myelin were produced. The MyVes have an average diameter of 100–150 nm, negative zeta potential, spheroidal morphology, and contain lipids and the key proteins of the myelin sheath. Furthermore, they exhibit good cytocompatibility. The MyVes were able to target the white matter and interact mainly with the microglia cells. The preliminary results here presented allow us to suppose the employment of MyVes as potential carrier to target the white matter and microglia in order to counteract white matter microglia-related diseases.

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Section: Methodsmentioning

confidence: 99%

Nano-structured myelin: new nanovesicles for targeted delivery to white matter and microglia, from brain-to-brain

Picone

Palumbo

Federico

et al. 2021

Materials Today Bio

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“…Liposomes are currently the most efficient and traditional drug delivery systems [1,2,9]. They are composed of phospholipids, which are the structural basis of all cell membranes, providing a good penetration of liposomes to cells.…”

Section: Lipid Nanocarriers Modified With Amphiphilic Moleculesmentioning

confidence: 99%

“…Therefore, serious efforts have been undertaken to develop further generations of liposomal carriers, including stealth (PEGylated), antibody-conjugated liposomes, etc. [1,2]. Meanwhile, the problem of instability in bioenvironment may be reduced by inducing the charge on the surface of liposomes.…”

Section: Lipid Nanocarriers Modified With Amphiphilic Moleculesmentioning

confidence: 99%

“…One of the ways to improve the effectiveness of medical therapies is the use of drug delivery systems. This makes it possible to increase bioavailability and biocompatibility of drugs, to optimize their release profile, overcome biological barriers, and control targeting properties, cellular uptake and intracellular trafficking [1][2][3]. Of particular interest is the delivery of anticancer drugs that can, in the future, reduce the severity of disease and mortality rate.…”

Section: Introductionmentioning

confidence: 99%

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Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Kashapov

Ibragimova

Pavlov

et al. 2021

IJMS

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Encapsulation of cargoes in nanocontainers is widely used in different fields to solve the problems of their solubility, homogeneity, stability, protection from unwanted chemical and biological destructive effects, and functional activity improvement. This approach is of special importance in biomedicine, since this makes it possible to reduce the limitations of drug delivery related to the toxicity and side effects of therapeutics, their low bioavailability and biocompatibility. This review highlights current progress in the use of lipid systems to deliver active substances to the human body. Various lipid compositions modified with amphiphilic open-chain and macrocyclic compounds, peptide molecules and alternative target ligands are discussed. Liposome modification also evolves by creating new hybrid structures consisting of organic and inorganic parts. Such nanohybrid platforms include cerasomes, which are considered as alternative nanocarriers allowing to reduce inherent limitations of lipid nanoparticles. Compositions based on mesoporous silica are beginning to acquire no less relevance due to their unique features, such as advanced porous properties, well-proven drug delivery efficiency and their versatility for creating highly efficient nanomaterials. The types of silica nanoparticles, their efficacy in biomedical applications and hybrid inorganic-polymer platforms are the subject of discussion in this review, with current challenges emphasized.

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“…Liposome, an artificially-made vesicle composed of lipid and cholesterol, possesses sound biocompatibility and drug loading capacity. However, clinical applications of liposomes are scarce due to their undesirable immunogenicity and unsatisfactory stability, biocompatibility, targeting ability, and absorbability (Antimisiaris et al, 2018;Guimarães et al, 2021). Such drawbacks can be largely overcome by fabricating an exosome-liposome complex, by which the advantages of two can complement each other (Haraszti et al, 2019;Sakai-Kato et al, 2020).…”

Section: Exosome Mimetic Liposomementioning

confidence: 99%

Techniques for increasing the yield of stem cell-derived exosomes: what factors may be involved?

Feng

Zhang

Tan

et al. 2021

Sci. China Life Sci.

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Exosomes are nano-scale extracellular vesicles secreted by cells and constitute an important part in the cell-cell communication. The main contents of the exosomes include proteins, microRNAs, and lipids. The mechanism and safety of stem cell-derived exosomes have rendered them a promising therapeutic strategy for regenerative medicine. Nevertheless, limited yield has restrained full explication of their functions and clinical applications To address this, various attempts have been made to explore the up- and down-stream manipulations in a bid to increase the production of exosomes. This review has recapitulated factors which may influence the yield of stem cell-derived exosomes, including selection and culture of stem cells, isolation and preservation of the exosomes, and development of artificial exosomes.

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Design of liposomes as drug delivery system for therapeutic applications

Cited by 651 publications

References 143 publications

Nano-structured myelin: new nanovesicles for targeted delivery to white matter and microglia, from brain-to-brain

Nano-structured myelin: new nanovesicles for targeted delivery to white matter and microglia, from brain-to-brain

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Techniques for increasing the yield of stem cell-derived exosomes: what factors may be involved?

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