Design of Materials for Bone Tissue Scaffolds

Boccaccio, Antonio

doi:10.3390/ma14205985

Cited by 8 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bone repair of tibial fractures, because it is endochondral ossification, occurs in a complex manner and can be divided into three main phases: inflammation, repair and remodeling [3][4][5], generally occurring outside the periosteum, in regions immediately adjacent to the fracture site and mechanically less stable [6][7][8]. For repair to occur effectively, it depends on a number of factors, such as care taken with the surgical environment, surgical margins, vascular proliferation, migration of undifferentiated cells, the presence of a fibrin network and, when possible, preserving the periosteum and endosteum [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Photobiomodulation Therapy Improves Repair of Bone Defects Filled by Inorganic Bone Matrix and Fibrin Heterologous Biopolymer

Vigliar,

Marega,

Duarte

et al. 2024

Bioengineering

View full text Add to dashboard Cite

Biomaterials are used extensively in graft procedures to correct bone defects, interacting with the body without causing adverse reactions. The aim of this pre-clinical study was to analyze the effects of photobiomodulation therapy (PBM) with the use of a low-level laser in the repair process of bone defects filled with inorganic matrix (IM) associated with heterologous fibrin biopolymer (FB). A circular osteotomy of 4 mm in the left tibia was performed in 30 Wistar male adult rats who were randomly divided into three groups: G1 = IM + PBM, G2 = IM + FB and G3 = IM + FB + PBM. PBM was applied at the time of the experimental surgery and three times a week, on alternate days, until euthanasia, with 830 nm wavelength, in two points of the operated site. Five animals from each group were euthanized 14 and 42 days after surgery. In the histomorphometric analysis, the percentage of neoformed bone tissue in G3 (28.4% ± 2.3%) was higher in relation to G1 (24.1% ± 2.91%) and G2 (22.2% ± 3.11%) at 14 days and at 42 days, the percentage in G3 (35.1% ± 2.55%) was also higher in relation to G1 (30.1% ± 2.9%) and G2 (31.8% ± 3.12%). In the analysis of the birefringence of collagen fibers, G3 showed a predominance of birefringence between greenish-yellow in the neoformed bone tissue after 42 days, differing from the other groups with a greater presence of red-orange fibers. Immunohistochemically, in all experimental groups, it was possible to observe immunostaining for osteocalcin (OCN) near the bone surface of the margins of the surgical defect and tartrate-resistant acid phosphatase (TRAP) bordering the newly formed bone tissue. Therefore, laser photobiomodulation therapy contributed to improving the bone repair process in tibial defects filled with bovine biomaterial associated with fibrin biopolymer derived from snake venom.

show abstract

Section: Introductionmentioning

confidence: 99%

Photobiomodulation Therapy Improves Repair of Bone Defects Filled by Inorganic Bone Matrix and Fibrin Heterologous Biopolymer

Vigliar,

Marega,

Duarte

et al. 2024

Bioengineering

View full text Add to dashboard Cite

show abstract

“…The scaffold must be designed to trigger the favorable biophysical stimuli, necessary for the formation of new bone tissue. The rate of bone tissue regeneration and the cellular response is influenced, in addition to the scaffold material composition, by the following: (a) the scaffold mechanical behavior, which is a function of the scaffold micro-architecture and of the mechanical properties of the material it is made from; (b) the surface roughness status and the biological/chemical response of the scaffold/tissue interface surfaces to external factors [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional-Printed Composite Scaffolds Containing Poly-ε-Caprolactone and Strontium-Doped Hydroxyapatite for Osteoporotic Bone Restoration

Codrea,

Lincu,

Ene

et al. 2024

Polymers

View full text Add to dashboard Cite

A challenge in tissue engineering and the pharmaceutical sector is the development of controlled local release of drugs that raise issues when systemic administration is applied. Strontium is an example of an effective anti-osteoporotic agent, used in treating osteoporosis due to both anti-resorptive and anabolic mechanisms of action. Designing bone scaffolds with a higher capability of promoting bone regeneration is a topical research subject. In this study, we developed composite multi-layer three-dimensional (3D) scaffolds for bone tissue engineering based on nano-hydroxyapatite (HA), Sr-containing nano-hydroxyapatite (SrHA), and poly-ε-caprolactone (PCL) through the material extrusion fabrication technique. Previously obtained HA and SrHA with various Sr content were used for the composite material. The chemical, morphological, and biocompatibility properties of the 3D-printed scaffolds obtained using HA/SrHA and PCL were investigated. The 3D composite scaffolds showed good cytocompatibility and osteogenic potential, which is specifically recommended in applications when faster mineralization is needed, such as osteoporosis treatment.

show abstract

“…Cheah et al [ 25 ] appraised the development, characterization, and biological performance of different materials obtained by synthesis with applications for bone, periodontal, and dental tissue regeneration, including CaP types of cement. This paper is a part of an interesting recent collection of research articles and reviews “describing numerical and experimental design techniques definitively aimed at improving the scaffold performance, shortening the healing time, and increasing the success rate of the scaffold implantation process”, as pointed out by Bocaccio [ 26 ]. Furthermore, it should be remarked that the use of CaP in cosmetics, as reviewed by Carella et al [ 27 ], shows the-state-of-the-art and future perspectives.…”

Section: Introductionmentioning

confidence: 99%

Effect of L-Glutamic Acid on the Composition and Morphology of Nanostructured Calcium Phosphate as Biomaterial

et al. 2023

View full text Add to dashboard Cite

Calcium phosphate (CaP) with several chemical compositions and morphologies was prepared by precipitation using aqueous solutions of L-Glutamic acid (H2G) and calcium hydroxide, both mixed together with an aqueous solution (0.15 M) of phosphoric acid. Plate-shaped dicalcium phosphate dihydrate (brushite) particles were obtained and identified at a lower concentration of the solution of the reactants. The Ca/P ratio deduced by EDS was ~1, as expected. The nanoscale dimension of carbonate apatite and amorphous calcium phosphate, with variable Ca/P ratios, were revealed by X-ray diffraction (XRD) and scanning electron microscopy and energy dispersive X-ray spectroscopy analysis (SEM-EDS). They were characterized in medium and high concentrations of calcium hydroxide (0.15 M and 0.20 M). The equilibria involved in all the reactions in aqueous solution were determined. The thermodynamic calculations showed a decrease in the amount of chelate complexes with an increase in pH, being the opposite of [CaPO4−] and [CaHG+]. This fluctuation showed an evident influence on the morphology and polymorphism of CaP particles obtained under the present experimental conditions, with potential use as a biomaterial.

show abstract

Design of Materials for Bone Tissue Scaffolds

Cited by 8 publications

References 23 publications

Photobiomodulation Therapy Improves Repair of Bone Defects Filled by Inorganic Bone Matrix and Fibrin Heterologous Biopolymer

Photobiomodulation Therapy Improves Repair of Bone Defects Filled by Inorganic Bone Matrix and Fibrin Heterologous Biopolymer

Three-Dimensional-Printed Composite Scaffolds Containing Poly-ε-Caprolactone and Strontium-Doped Hydroxyapatite for Osteoporotic Bone Restoration

Effect of L-Glutamic Acid on the Composition and Morphology of Nanostructured Calcium Phosphate as Biomaterial

Contact Info

Product

Resources

About