2023
DOI: 10.1007/s13346-023-01316-9
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Design of mirtazapine solid dispersion with different carriers’ systems: optimization, in vitro evaluation, and bioavailability assessment

Abstract: The solid dispersion technique is the most effective and widely used approach for increasing the solubility and release of drugs that have low water solubility. Mirtazapine (MRT) is an atypical antidepressant used to treat severe depression. MRT has a low oral bioavailability (about 50%) due to its low water solubility (BCS class II). The study’s goal was to determine optimum conditions for incorporating MRT into various polymer types utilizing the solid dispersion (SD) technique, with the goal of selecting th… Show more

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Cited by 6 publications
(2 citation statements)
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“…The D-optimal design was used to investigate the principle and interactive variable effects on the examined responses by using Design-Expert ® software, version 13 [ 20 ]. An initial screening of the independent factors as drug/MSN percentage (A), coat concentration percentage (B), and MSN type (C) was conducted to select the most effective of them on the chosen dependent factors.…”
Section: Methodsmentioning
confidence: 99%
“…The D-optimal design was used to investigate the principle and interactive variable effects on the examined responses by using Design-Expert ® software, version 13 [ 20 ]. An initial screening of the independent factors as drug/MSN percentage (A), coat concentration percentage (B), and MSN type (C) was conducted to select the most effective of them on the chosen dependent factors.…”
Section: Methodsmentioning
confidence: 99%
“…As for its solubility, there seem to be some discrepancies in scientific literature. While, the online Biopharmaceutical classification system (BCS) database puts MRT in the high solubility, high permeability BCS class I [8], scientific articles mention its positive log P coefficient (2.9 [3, 9, 10] and 3.3 [11]) and place MRT in the low solubility, high permeability BCS class II [12]. Considering, the log P coefficient and the reported high solubility in solid lipids [10], a high-water solubility seems unlikely and MRT's inclusion in the BCS class II appears more plausible.…”
Section: Introductionmentioning
confidence: 99%