Design of Monitoring and Sensor Systems for Bioprocesses by Biomechatronic Methodology

Abstract

Biomechatronic design methodology is discussed for the design of monitoring and sensor systems for biotechnological processes. The bioprocess monitoring systems are examples of complex biomechatronic systems between electronic, mechanical, and biological subsystems, and where in particular the biological parts, through active microbial or cellular components, influence the design solutions in a complex manner. The biomechatronic approach facilitates configuration of the monitoring and sensor systems with production and quality needs in focus, and can by that lead to more efficient design solutions.

Mini‐review: soft sensors as means for PAT in the manufacture of bio‐therapeutics

“…The design of process analytical systems for a pharmaceutical production process, from a PAT perspective or any other viewpoint, seldom starts with a thorough analysis of the manufacturer's actual needs. This should however be the first step to take, as is commonly done with other engineering design tasks …”

“…When the analytical needs listed in Table are provided with target values a much more precise map of the manufacturer needs can be stated . This allows ranking the importance of analytical needs, which would facilitate design of the analytical system . With support of the mapping the boundaries for the design of the analytical system are set.…”

“…A ranking (e.g. as suggested by Mandenius and Björkman) of analytical performance versus user requirements might be an efficient way to select the most relevant soft sensor configuration. This should also at some level involve an economic assessment …”

Conceptual Design of Micro-Bioreactors and Organ-on-Chips for Studies of Cell Cultures

“…In industrial design, conceptual methodology is widely applied to mechanical and electrical products [ 40 ]. However, in bioengineering it has been so far rarely used, with only a few examples on bioreactor scale-up [ 41 , 42 ], bioprocess configuration, monitoring and control [ 43 , 44 ], and stem cell production [ 45 , 46 ], but also recently for organ-on-chips [ 47 ].…”

Conceptual Design of an Operator Training Simulator for a Bio-Ethanol Plant

“…They provide the spatial and temporal functions for the conversion by the biological systems of the raw material streams under defined physical and chemical conditions. Here, the components of the biological conversion are separated and concentrated by grinding, gravity, transport, vaporization and partitioning [32,33]. The TS also include the software functions that allow mathematical models to be computed in real time in the OTS as well as a function for accelerating the simulation.…”