2022
DOI: 10.3389/fonc.2022.993725
|View full text |Cite
|
Sign up to set email alerts
|

Design of new drugs for medullary thyroid carcinoma

Abstract: Medullary thyroid carcinoma (MTC) is one of the common malignant endocrine tumors, which seriously affects human health. Although surgical resection offers a potentially curative therapeutic option to some MTC patients, most patients do not benefit from it due to the difficulty to access the tumors and tumor metastasis. The survival rate of MTC patients has improved with the recent advances in the research, which has improved our understanding of the molecular mechanism underlying MTC and enabled the developme… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

0
3
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
(3 citation statements)
references
References 103 publications
0
3
0
Order By: Relevance
“…By identifying and targeting these specific abnormalities, we can effectively inhibit tumor growth and improve patient outcomes. 8 Follicular cells transform into different types of TC after undergoing certain mutations as depicted in Figure 2C. In papillary thyroid carcinoma, 30-70% have BRAF V600E mutation, and 7% have translocation of RET/PTC.…”
Section: Pathophysiologymentioning
confidence: 99%
See 2 more Smart Citations
“…By identifying and targeting these specific abnormalities, we can effectively inhibit tumor growth and improve patient outcomes. 8 Follicular cells transform into different types of TC after undergoing certain mutations as depicted in Figure 2C. In papillary thyroid carcinoma, 30-70% have BRAF V600E mutation, and 7% have translocation of RET/PTC.…”
Section: Pathophysiologymentioning
confidence: 99%
“…The mechanisms underlying combined therapies that include immunemediated checkpoint barriers against Pd1 or Pdl1 prevent PDL1 and PDL2 from reducing each other's inhibiting properties in the tumor microenvironment. 8 As a result, blocking the PD1 axis increases the strength of T cells' anticancer response and the expansion of natural killers (NK).…”
Section: Pathophysiologymentioning
confidence: 99%
See 1 more Smart Citation