This work focused on the mathematical model establishment and accurately forecast the conditions of thermal storage catalytic combustion about ethyl acetate, using platinum/palladium molecular sieve support reaction system. According to the physical properties of ethyl acetate and the mass transfer and continuity equations, a mathematical model was established using FORTRAN programming. The mathematical model was used to calculate the removal rate of ethyl acetate at switching time and processing flow rate. Under the same conditions, the model and experiment proved that the removal rate of ethyl acetate was above 98%, indicating that the model provides a valid data for a deeper understanding of the thermal storage catalytic combustion. The accuracy of the model is verified by the experimentally measured bed temperature when compared with the calculated. This work can provide a valuable tool to prevent the reactor from ‘over temperature' or ‘flaming out' in thermal storage catalytic combustion process.